Methyl L-tryptophanate hydrochloride
Methyl L-tryptophanate hydrochloride structure
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Common Name | Methyl L-tryptophanate hydrochloride | ||
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| CAS Number | 7524-52-9 | Molecular Weight | 254.713 | |
| Density | N/A | Boiling Point | 390.6ºC at 760 mmHg | |
| Molecular Formula | C12H15ClN2O2 | Melting Point | 218-220ºC | |
| MSDS | USA | Flash Point | 190ºC | |
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Inhibition of indoleamine 2,3-dioxygenase activity by levo-1-methyl tryptophan blocks gamma interferon-induced Chlamydia trachomatis persistence in human epithelial cells.
Infect. Immun. 79 , 4425-4437, (2011) Gamma interferon (IFN-γ) induces expression of the tryptophan-catabolizing enzyme indoleamine 2,3-dioxygenase (IDO1) in human epithelial cells, the permissive cells for the obligate intracellular bacterium Chlamydia trachomatis. IDO1 depletes tryptophan by ca... |
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Clinical significance of tryptophan metabolism in the nontumoral hemisphere in patients with malignant glioma.
J. Nucl. Med. 55(10) , 1605-10, (2014) α-(11)C-methyl-L-tryptophan (AMT) PET allows evaluation of brain serotonin synthesis and can also track upregulation of the immunosuppressive kynurenine pathway in tumor tissue. Increased AMT uptake is a hallmark of World Health Organization grade III-IV glio... |
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Transport and signaling via the amino acid binding site of the yeast Gap1 amino acid transceptor.
Nat. Chem. Biol. 5 , 45-52, (2009) Transporter-related nutrient sensors, called transceptors, mediate nutrient activation of signaling pathways through the plasma membrane. The mechanism of action of transporting and nontransporting transceptors is unknown. We have screened 319 amino acid anal... |
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Functionalized nanocarrier combined seizure-specific vector with P-glycoprotein modulation property for antiepileptic drug delivery.
Biomaterials 74 , 64-76, (2015) Despite optimal therapeutic regimen with currently available antiepileptic drugs (AEDs), approximately a third of epilepsy patients remain drug refractory. Region-specific overexpression of multidrug efflux transporters at the blood-brain barrier, such as P-g... |
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Mouse model for allogeneic immune reaction against fetus recapitulates human pre-eclampsia.
J. Obstet. Gynaecol. Res. 34(1) , 1-6, (2008) We have previously demonstrated that mRNA expression and enzyme activity levels of placental indoleamine 2,3-dioxygenase (IDO), which degrades L-tryptophan and blocks the proliferation of T cells, are significantly low in patients with severe pre-eclampsia. F... |
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Abnormal brain tryptophan metabolism and clinical correlates in Tourette syndrome.
Mov. Disord 22(15) , 2256-62, (2007) Symptoms in Tourette syndrome (TS) are likely related to abnormalities involving multiple neurotransmitter systems in striatal-thalamo-cortical circuitry. Although prior studies have found abnormal levels of tryptophan, serotonin, and their metabolites in blo... |
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Functionalized magnetonanoparticles for MRI diagnosis and localization in epilepsy.
Epilepsia 49(8) , 1419-30, (2008) The development of nonradioactive and targeted magnetonanoparticles (MNP) capable of crossing the blood-brain barrier (BBB) and of concentrating in the epileptogenic tissues of acute and chronic animal models of temporal lobe epilepsy to render these tissues ... |
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Mesenchymal stem cells can induce long-term acceptance of solid organ allografts in synergy with low-dose mycophenolate.
Transpl. Immunol. 20(1-2) , 55-60, (2008) The induction of tolerance towards allogeneic solid organ grafts is one of the major goals in transplantation medicine. Mesenchymal stem cells (MSC) inhibit the immune response in vitro, and thus are promising candidate cells to promote acceptance of transpla... |
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Tumor immune escape mediated by indoleamine 2,3-dioxygenase.
Immunol. Lett. 111(2) , 69-75, (2007) Amongst the numerous mediators contributing towards the escape of tumors from the host's immune response against them, the enzyme indoleamine 2,3-dioxygenase (IDO) has recently attracted special attention. By catabolizing tryptophan to N-formyl-kynurenine, ID... |
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Cis-diastereoselectivity in pictet-spengler reactions of L-tryptophan and electronic circular dichroism studies.
Chirality 24(10) , 789-95, (2012) The diastereoselective synthesis of optically active 1,3-disubstituted tetrahydro-β-carbolines using polar protic Pictet-Spengler cyclization of (S)-tryptophan methyl ester with five aldehydes RCHO (R═CH(3), C(2)H(5), C(3)H(7), C(4)H(9), and C(6)H(5)) was stu... |