DL-Tyrosine

DL-Tyrosine Structure
DL-Tyrosine structure
Common Name DL-Tyrosine
CAS Number 556-03-6 Molecular Weight 181.189
Density 1.3±0.1 g/cm3 Boiling Point 385.2±32.0 °C at 760 mmHg
Molecular Formula C9H11NO3 Melting Point >300ºC
MSDS Chinese USA Flash Point 186.7±25.1 °C

DNase II-dependent DNA digestion is required for DNA sensing by TLR9.

Nat. Commun. 6 , 5853, (2015)

DNase II digests DNA in endolysosomes. In the absence of DNase II, undigested DNA activates cytoplasmic DNA-sensing pathways. Little is known, however, about the role of DNase II in endolysosomal DNA sensing by TLR9. Here we show that DNase II is required for...

Gene therapy with AAV2-CDNF provides functional benefits in a rat model of Parkinson's disease.

Brain Behav. 3(2) , 75-88, (2013)

Cerebral dopamine neurotrophic factor (CDNF) protein has been shown to protect the nigrostriatal dopaminergic pathway when given as intrastriatal infusions in rat and mouse models of Parkinson's disease (PD). In this study, we assessed the neuroprotective eff...

RCCS bioreactor-based modelled microgravity induces significant changes on in vitro 3D neuroglial cell cultures.

Biomed Res. Int. 2015 , 754283, (2015)

We propose a human-derived neuro-/glial cell three-dimensional in vitro model to investigate the effects of microgravity on cell-cell interactions. A rotary cell-culture system (RCCS) bioreactor was used to generate a modelled microgravity environment, and mo...

A simplified method to recover urinary vesicles for clinical applications, and sample banking.

Sci. Rep. 4 , 7532, (2014)

Urinary extracellular vesicles provide a novel source for valuable biomarkers for kidney and urogenital diseases: Current isolation protocols include laborious, sequential centrifugation steps which hampers their widespread research and clinical use. Furtherm...

FGFR1 mediates recombinant thrombomodulin domain-induced angiogenesis.

Cardiovasc. Res. 105(1) , 107-17, (2014)

The recombinant epidermal growth factor-like domain plus the serine/threonine-rich domain of thrombomodulin (rTMD23) promotes angiogenesis and accelerates the generation of activated protein C (APC), which facilitates angiogenesis. The aim of this study was t...

miR-154* and miR-379 in the DLK1-DIO3 microRNA mega-cluster regulate epithelial to mesenchymal transition and bone metastasis of prostate cancer.

Clin. Cancer Res. 20(24) , 6559-69, (2014)

MicroRNAs in the delta-like 1 homolog-deiodinase, iodothyronine 3 (DLK1-DIO3) cluster have been shown to be critical for embryonic development and epithelial to mesenchymal transition (EMT). DLK1-DIO3 cluster miRNAs are elevated in the serum of patients with ...

Cisplatin at sub-toxic levels mediates integrin switch in lung cancer cells.

Anticancer Res. 34(12) , 7111-7, (2014)

Resistance to chemotherapeutic agents, as well as enhanced metastasis, have been frequently reported in lung cancer.Cytotoxicity and proliferative effects of cisplatin on H460 lung cancer cells were evaluated by the MTT assay. Migration capacity was evaluated...

Mechanism of chemical activation of sodium chloride in the presence of amino acids.

Food Chem. 166 , 301-8, (2014)

Sodium chloride has been shown to promote chlorination of glycerol during thermal processing. However, the detailed mechanism of this reaction is not well understood. Preliminary experiments have indicated that the reaction mixture should contain an amino aci...

Targeting cell surface TLR7 for therapeutic intervention in autoimmune diseases.

Nat. Commun. 6 , 6119, (2015)

Toll-like receptor 7 (TLR7) senses microbial-derived RNA but can also potentially respond to self-derived RNA. To prevent autoimmune responses, TLR7 is thought to localize in endolysosomes. Contrary to this view, we show here that TLR7 is present on the cell ...

Characterization of axons expressing the artemin receptor in the female rat urinary bladder: a comparison with other major neuronal populations.

J. Comp. Neurol. 522(17) , 3900-27, (2014)

Artemin is a member of the glial cell line-derived neurotrophic factor (GDNF) family that has been strongly implicated in development and regeneration of autonomic nerves and modulation of nociception. Whereas other members of this family (GDNF and neurturin)...