Stearoyl coenzyme A lithium
Stearoyl coenzyme A lithium structure
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Common Name | Stearoyl coenzyme A lithium | ||
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| CAS Number | 193402-48-1 | Molecular Weight | 1034 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C39H66Li4N7O17P3S | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
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Stearoyl-CoA desaturase: a vital checkpoint in the development and progression of obesity.
Endocr. Metab. Immune Disord. Drug Targets 11 , 217-231, (2011) Stearoyl-CoA desaturase 1 (SCD-1) is the rate-limiting enzyme that catalyses the conversion of saturated to monounsaturated fatty acids. Increased SCD-1 expression and activity has been implicated in cancer, cardiovascular diseases, insulin resistance and obe... |
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Stearoyl-CoA desaturase-1: a novel key player in the mechanisms of cell proliferation, programmed cell death and transformation to cancer.
Carcinogenesis 31 , 1509-1515, (2010) As part of a shift toward macromolecule production to support continuous cell proliferation, cancer cells coordinate the activation of lipid biosynthesis and the signaling networks that stimulate this process. A ubiquitous metabolic event in cancer is the con... |
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Elevated stearoyl-CoA desaturase in brains of patients with Alzheimer's disease.
PLoS ONE 6 , e24777, (2011) The molecular bases of Alzheimer's disease (AD) remain unclear. We used a lipidomic approach to identify lipid abnormalities in the brains of subjects with AD (N = 37) compared to age-matched controls (N = 17). The analyses revealed statistically detectable e... |
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Distinct regulation of stearoyl-CoA desaturase 1 gene expression by cis and trans C18:1 fatty acids in human aortic smooth muscle cells.
Genes Nutr. 7(2) , 209-16, (2011) Consumption of trans fatty acids is positively correlated with cardiovascular diseases and with atherogenic risk factors. Trans fatty acids might play their atherogenic effects through lipid metabolism alteration of vascular cells. Accumulation of lipids in v... |
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Inhibition of stearoyl-CoA desaturase1 activates AMPK and exhibits beneficial lipid metabolic effects in vitro.
Eur. J. Pharmacol. 672(1-3) , 38-44, (2011) Stearoyl-CoA desaturase1 (SCD1) whole body deficiency protects mice from diet-induced obesity. However the specific mechanism of how SCD1 deficiency protects mice from obesity is not clear yet. To understand the tissue-specific role of SCD1 in energy homeosta... |