Indole-3-carboxaldehyde
Indole-3-carboxaldehyde structure
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Common Name | Indole-3-carboxaldehyde | ||
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| CAS Number | 487-89-8 | Molecular Weight | 145.158 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 339.1±15.0 °C at 760 mmHg | |
| Molecular Formula | C9H7NO | Melting Point | 193-198 °C(lit.) | |
| MSDS | USA | Flash Point | 166.8±27.8 °C | |
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A chemical screening approach reveals that indole fluorescence is quenched by pre-fibrillar but not fibrillar amyloid-beta.
Bioorg. Med. Chem. Lett. 19 , 4952-7, (2009) Aggregated amyloid-beta (Abeta) peptide is implicated in the pathology of Alzheimer's disease. In vitro and in vivo, these aggregates are found in a variety of morphologies, including globular oligomers and linear fibrils, which possess distinct biological ac... |
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Antioxidative properties of ascorbigen in using multiple antioxidant assays.
Biosci. Biotechnol. Biochem. 78(10) , 1723-30, (2014) The antioxidative properties of ascorbigen, one of the major indole-derived compounds of Brassica vegetables, were systematically evaluated using multiple assay systems with comparison to the well-known antioxidants ascorbic acid and Trolox. We first performe... |
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Rational design of novel CYP2A6 inhibitors.
Bioorg. Med. Chem. 22(23) , 6655-64, (2015) Inhibition of CYP2A6-mediated nicotine metabolism can reduce cigarette smoking. We sought potent and selective CYP2A6 inhibitors to be used as leads for drugs useful in smoking reduction therapy, by evaluating CYP2A6 inhibitory effect of novel formyl, alkyl a... |
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Characterization of microbial dysbiosis and metabolomic changes in dogs with acute diarrhea.
PLoS ONE 10 , e0127259, (2015) Limited information is available regarding the metabolic consequences of intestinal dysbiosis in dogs with acute onset of diarrhea. The aim of this study was to evaluate the fecal microbiome, fecal concentrations of short-chain fatty acids (SCFAs), as well as... |
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Virtual screening identification of nonfolate compounds, including a CNS drug, as antiparasitic agents inhibiting pteridine reductase.
J. Med. Chem. 54 , 211-221, (2011) Folate analogue inhibitors of Leishmania major pteridine reductase (PTR1) are potential antiparasitic drug candidates for combined therapy with dihydrofolate reductase (DHFR) inhibitors. To identify new molecules with specificity for PTR1, we carried out a vi... |
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A family of indoles regulate virulence and Shiga toxin production in pathogenic E. coli.
PLoS ONE 8(1) , e54456, (2013) Enteropathogenic Escherichia coli (EPEC), enterohemorrhagic E. coli (EHEC) and enteroaggregative E. coli (EAEC) are intestinal pathogens that cause food and water-borne disease in humans. Using biochemical methods and NMR-based comparative metabolomics in con... |
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Aniline-induced tryptophan production and identification of indole derivatives from three purple bacteria.
Curr. Microbiol. 61(4) , 285-90, (2010) Growth on aniline by three purple non-sulfur bacteria (Rhodospirillum rubrum ATCC 11170, Rhodobacter sphaeroides DSM 158, and Rubrivivax benzoatiliticus JA2) as nitrogen, or carbon source could not be demonstrated. However in its presence, production of indol... |
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An efficient one-step synthesis of heterobiaryl pyrazolo[3,4-b]pyridines via indole ring opening.
Org. Lett. 11(22) , 5214-7, (2009) A mild one-step synthetic method to access privileged heterobiaryl pyrazolo[3,4-b]pyridines from indole-3-carboxaldehyde derivatives and a variety of aminopyrazoles has been developed. This novel method constructs heterobiaryls with the wide scope of substrat... |
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Discovery of novel antileishmanial agents in an attempt to synthesize pentamidine-aplysinopsin hybrid molecule.
J. Med. Chem. 52 , 5793-802, (2009) In an attempt to synthesize pentamidine-aplysinopsin hybrid molecule 25, a lead molecule 8 (containing Z-configured aplysinopsin moiety) was identified for antileishmanial activity. Optimization of lead 8 provided 24 (containing E-configured aplysinopsin) pos... |
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[Chemical constituents from aerial parts of Plumbago zeylanica Linn].
Zhong Yao Cai 30(5) , 558-60, (2007) To investigate the chemical constituents of the aerial parts of Plumbago zeylanica Linn.The constituents of the EtOAc-soluble portion in the 95% ethanol extract were isolated and purified by means of chromatography. Compounds were identified by their physical... |