N-Glycolylneuraminic acid
N-Glycolylneuraminic acid structure
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Common Name | N-Glycolylneuraminic acid | ||
|---|---|---|---|---|
| CAS Number | 1113-83-3 | Molecular Weight | 325.269 | |
| Density | 1.9±0.1 g/cm3 | Boiling Point | 826.1±75.0 °C at 760 mmHg | |
| Molecular Formula | C11H19NO10 | Melting Point | 188-190°C | |
| MSDS | Chinese USA | Flash Point | 453.4±37.1 °C | |
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The role of sialyl glycan recognition in host tissue tropism of the avian parasite Eimeria tenella.
PLoS Pathog. 7(10) , e1002296, (2011) Eimeria spp. are a highly successful group of intracellular protozoan parasites that develop within intestinal epithelial cells of poultry, causing coccidiosis. As a result of resistance against anticoccidial drugs and the expense of manufacturing live vaccin... |
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Determination of sialic acids in milks and milk-based products.
Anal. Biochem. 405(1) , 28-40, (2010) Sialic acids are becoming recognized as important components of milk-based products for infants and young children. As such, many companies now label the sialic acid content of their products. To control the labeling, suitable methods are required for this an... |
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Production of monoclonal antibodies directed to Hanganutziu-Deicher active gangliosides, N-glycolylneuraminic acid-containing gangliosides.
J. Biochem. 117(5) , 1062-9, (1995) We have established three kinds of monoclonal antibodies against gangliosides containing N-glycolylneuraminic acid (NeuGc) by immunization of BALB/c mice with the purified gangliosides inserted into liposomes comprising Salmonella minnesota R595 lipopolysacch... |
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N-glycolylneuraminic acid deficiency in humans.
Biochimie 83(7) , 615-22, (2001) Classic studies suggested that the common mammalian sialic acid N-glycolylneuraminic acid (Neu5Gc) is an oncofetal antigen in humans, being immunogenic in adult humans and yet apparently expressed in human fetuses and tumors. We and others have recently found... |
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Purification, characterization, and sugar binding specificity of an N-Glycolylneuraminic acid-specific lectin from the mushroom Chlorophyllum molybdites.
J. Biol. Chem. 279(51) , 53048-55, (2004) A carbohydrate-binding protein was isolated from the carpophores of the mushrooms and designated the Chlorophyllum molybdites lectin (CML) based on its origin. The molecular mass of CML was 32 kDa, and it was composed of two 16-kDa monomers with no disulfide ... |
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Sexual selection by female immunity against paternal antigens can fix loss of function alleles.
Proc. Natl. Acad. Sci. U. S. A. 108(43) , 17743-8, (2011) Humans lack the common mammalian cell surface molecule N-glycolylneuraminic acid (Neu5Gc) due to a CMAH gene inactivation, which occurred approximately three million years ago. Modern humans produce antibodies specific for Neu5Gc. We hypothesized that anti-Ne... |
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A novel analytical probe binding to a potential carcinogenic factor of N-glycolylneuraminic acid by SELEX.
Biosens. Bioelectron. 49 , 547-54, (2013) N-glycolylneuraminic acid (Neu5Gc) is an abundant sialic acid in many mammals and is present in the glycoconjugates of most deuterostome animals. Neu5Gc also occurs in fresh samples of human tumors and fetuses. However, very little is known about the expressi... |
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Sialic acid speciation using capillary electrophoresis: optimization of analyte derivatization and separation.
Anal. Chem. 84(18) , 7638-42, (2012) Capillary electrophoresis with laser induced fluorescence detection (CE-LIF) was employed for rapid sialic acid speciation, facilitating the quantitative determination of N-glycolylneuraminic acid (Neu5Gc) and N-acetylneuraminic acid (Neu5Ac) on glycoproteins... |
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Deficiency of N-glycolylneuraminic acid and Galα1-3Galβ1-4GlcNAc epitopes in xenogeneic cells attenuates cytotoxicity of human natural antibodies.
Xenotransplantation 17(6) , 440-8, (2010) A number of carbohydrate structures apart from Galα1-3Galβ1-4GlcNAc (Gal) have been implicated as potential xenoantigens. Epitopes of another carbohydrate structure, namely N-glycolylneuraminic acid (NeuGc), are widely expressed on the surfaces of endothelial... |
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Specific detection of N-glycolylneuraminic acid and Galα1-3Gal epitopes of therapeutic antibodies by partial-filling capillary electrophoresis.
Anal. Biochem. 431(2) , 120-6, (2012) The oligosaccharide structure is very important in biopharmaceuticals because of its effects on protein function, including efficacy and half-life. N-glycolylneuraminic acid (Neu5Gc) and Galα1-3Gal (α-Gal) residues are known to show immunogenicity in humans. ... |