Clopidogrel bisulfate
Clopidogrel bisulfate structure
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Common Name | Clopidogrel bisulfate | ||
|---|---|---|---|---|
| CAS Number | 120202-66-6 | Molecular Weight | 419.900 | |
| Density | N/A | Boiling Point | 423.7ºC at 760 mmHg | |
| Molecular Formula | C16H18ClNO6S2 | Melting Point | 184ºC | |
| MSDS | Chinese USA | Flash Point | 210ºC | |
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Environmental friendly method for urban wastewater monitoring of micropollutants defined in the Directive 2013/39/EU and Decision 2015/495/EU.
J. Chromatogr. A. 1418 , 140-9, (2015) The fate and removal of organic micropollutants in the environment is a demanding issue evidenced by the recent European policy. This work presents an analytical method for the trace quantification of 37 micropollutants including Priority Substances (Directiv... |
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RASA3 is a critical inhibitor of RAP1-dependent platelet activation.
J. Clin. Invest. 125(4) , 1419-32, (2015) The small GTPase RAP1 is critical for platelet activation and thrombus formation. RAP1 activity in platelets is controlled by the GEF CalDAG-GEFI and an unknown regulator that operates downstream of the adenosine diphosphate (ADP) receptor, P2Y12, a target of... |
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Comparison of substrate specificity among human arylacetamide deacetylase and carboxylesterases.
Eur. J. Pharm. Sci. 78 , 47-53, (2015) Human arylacetamide deacetylase (AADAC) is an esterase responsible for the hydrolysis of some drugs, including flutamide, indiplon, phenacetin, and rifamycins. AADAC is highly expressed in the human liver, where carboxylesterase (CES) enzymes, namely, CES1 an... |
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Dendrimer-like assemblies based on organoclays as multi-host system for sustained drug delivery.
Eur. J. Pharm. Biopharm. 88(3) , 706-17, (2014) Chemical modification of nanoclay will ensure further progress on these materials. In this work, we show that montmorillonite (MTM) nanosheets can be modified with β-cyclodextrin (CD) via a nucleophilic substitution reaction between mono-6-(p-toluenesulfonyl)... |
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A modified stapling technique for the repair of an aneurysmal autogenous arteriovenous fistula.
J. Vasc. Surg. 60(4) , 1019-23, (2014) An alternative surgical technique for the repair an aneurysmatic arteriovenous fistula (AVF) using a staple remodeling operation has been developed and the results are reported.All patients presenting with an aneurysmatic autogenous AVF of the upper extremiti... |
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Embolization of the first diagonal branch of the left anterior descending coronary artery as a porcine model of chronic trans-mural myocardial infarction.
J. Transl. Med. 13 , 187, (2015) Although the incidence of acute death related to coronary artery disease has decreased with the advent of new interventional therapies, myocardial infarction remains one of the leading causes of death in the US. Current animal models developed to replicate th... |
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Antiplatelet Efficacy of Fixed-Dose Aspirin-Clopidogrel Combination in Patients with Stable Coronary Artery Disease Treated with Drug-Eluting Stent Implantation.
Clin. Drug Investig. 35 , 833-42, (2015) A fixed-dose combination (FDC) of aspirin and clopidogrel bisulfate may improve medication adherence. However, the absence of data on the relative antiplatelet efficacy of FDC and separate dual pills (SDP) of aspirin and clopidogrel in real-world patients wit... |
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The innate immune system contributes to tissue-engineered vascular graft performance.
FASEB J. 29 , 2431-8, (2015) The first clinical trial of tissue-engineered vascular grafts (TEVGs) identified stenosis as the primary cause of graft failure. In this study, we aimed to elucidate the role of the host immune response in the development of stenosis using a murine model of T... |
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Inhibition of COX-1 attenuates the formation of thromboxane A2 and ameliorates the acute decrease in glomerular filtration rate in endotoxemic mice.
Am. J. Physiol. Renal Physiol. 309 , F332-40, (2015) Thromboxane (Tx) A2 has been suggested to be involved in the development of sepsis-induced acute kidney injury (AKI). Therefore, we investigated the impact of cyclooxygenase (COX)-1 and COX-2 activity on lipopolysaccharide (LPS)-induced renal TxA2 formation, ... |
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A sensitive and rapid ultra HPLC-MS/MS method for the simultaneous detection of clopidogrel and its derivatized active thiol metabolite in human plasma.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 880(1) , 132-9, (2012) A sensitive, selective, and rapid ultra-high performance liquid chromatography-tandem mass spectrometry (uHPLC-MS/MS) was developed for the simultaneous quantification of clopidogrel (Plavix(®)) and its derivatized active metabolite (CAMD) in human plasma. De... |