Isosorbide 5-mononitrate
Isosorbide 5-mononitrate structure
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Common Name | Isosorbide 5-mononitrate | ||
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| CAS Number | 16051-77-7 | Molecular Weight | 191.139 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 364.5±42.0 °C at 760 mmHg | |
| Molecular Formula | C6H9NO6 | Melting Point | 88-93 °C | |
| MSDS | N/A | Flash Point | 174.2±27.9 °C | |
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In vitro and in vivo evaluation of novel osmotic pump tablets of isosorbide-5-mononitrate containing polyvinyl pyrrolidone (PVP) for controlled release.
Pharmazie 67(8) , 695-700, (2012) A novel osmotic pump tablet with ethyl cellulose (EC) and polyvinyl pyrrolidone (PVP) as the semipermeable membrane and isosorbide-5-mononitrate (5-ISMN) as the model drug was formulated in this study. Zero order release kinetics were attained by avoiding agi... |
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Vascular dysfunction in experimental diabetes is improved by pentaerithrityl tetranitrate but not isosorbide-5-mononitrate therapy.
Diabetes 60(10) , 2608-16, (2011) Diabetes is associated with vascular oxidative stress, activation of NADPH oxidase, and uncoupling of nitric oxide (NO) synthase (endothelial NO synthase [eNOS]). Pentaerithrityl tetranitrate (PETN) is an organic nitrate with potent antioxidant properties via... |
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A randomized phase II study of irinotecan plus cisplatin versus irinotecan plus capecitabine with or without isosorbide-5-mononitrate in advanced non-small-cell lung cancer.
Ann. Oncol. 23(11) , 2925-30, (2012) We investigated the efficacy of irinotecan/cisplatin (IP) versus irinotecan/capecitabine (IX) with or without isosorbide-5-mononitrate (ISMN) in chemo-naïve advanced non-small-cell lung cancer.Initially, 74 patients were randomly assigned to either IP or IX. ... |
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Intravenous diuretic and vasodilator therapy reduce plasma brain natriuretic peptide levels in acute exacerbation of chronic obstructive pulmonary disease.
Respirology 17(4) , 715-20, (2012) Plasma concentrations of brain natriuretic peptide (BNP) are elevated in patients with chronic obstructive pulmonary disease (COPD), and high plasma BNP levels are associated with a poor prognosis. We aimed to evaluate the effects of a diuretic and a vasodila... |
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In vitro dissolution and in vivo bioequivalence evaluation of two brands of isosorbide 5-mononitrate sustained release tablets.
Arzneimittelforschung 62(12) , 576-82, (2012) The purpose of the present study was to test a sustained release-tablet newly formulated with synthetic paraffin and compare its bioequivalence to that of the Imdur® Long-Acting tablet, based on the guidelines of the Korean Food and Drug Administration.Dissol... |
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Randomized, controlled trial of carvedilol versus nadolol plus isosorbide mononitrate for the prevention of variceal rebleeding.
J. Gastroenterol. Hepatol. 27(11) , 1681-7, (2012) Carvedilol has been shown to be more effective than propranolol in decreasing portal pressure. Sufficient data from controlled trials remains limited. This trial compared the relative safety and efficacy between carvedilol and nadolol plus isosorbide mononitr... |
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Evaluation of isosorbide mononitrate for cervical ripening prior to induction of labor for postdated pregnancy in an outpatient setting.
Int. J. Gynaecol. Obstet. 118(3) , 205-9, (2012) To determine the safety and effectiveness of self-administered treatment with isosorbide mononitrate (IMN) for cervical ripening in Indian women with postdated pregnancies.A randomized, placebo-controlled study was conducted with 200 women with postdated preg... |
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Interruption of a study of cervical ripening with isosorbide mononitrate due to adverse effects.
Clin. Exp. Obstet. Gynecol. 39(2) , 175-80, (2012) The objective of this study was to evaluate cervix length and the presence of cervical gland area (CGA) in ultrasounds performed before and after the administration of vaginal isosorbide mononitrate (IMN) for cervical ripening.We performed an observational, d... |
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Pakistan's deadly cocktail of substandard drugs.
Lancet 379(9821) , 1084-5, (2012)
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Contaminated drugs are held responsible for 120 deaths in Pakistan.
BMJ 344 , e951, (2012)
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