Tobramycin
Tobramycin structure
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Common Name | Tobramycin | ||
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| CAS Number | 32986-56-4 | Molecular Weight | 467.514 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 775.4±60.0 °C at 760 mmHg | |
| Molecular Formula | C18H37N5O9 | Melting Point | 178ºC | |
| MSDS | Chinese USA | Flash Point | 422.8±32.9 °C | |
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Aminoglycosides suppress the protein folding activity of the molecular chaperone HSC70: implication of a structure-activity relationship.
Chemotherapy 60(1) , 37-46, (2014) The mechanism of aminoglycoside (AG)-induced nephrotoxicity has not been fully elucidated. We previously reported that gentamicin suppresses the functions of HSC70, a heat shock cognate protein, which is a cytosolic molecular chaperone in mammalian cells. How... |
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Pseudomonas aeruginosa Biofilm Formation and Persistence, along with the Production of Quorum Sensing-Dependent Virulence Factors, Are Disrupted by a Triterpenoid Coumarate Ester Isolated from Dalbergia trichocarpa, a Tropical Legume.
PLoS ONE 10 , e0132791, (2015) Recently, extracts of Dalbergia trichocarpa bark have been shown to disrupt P. aeruginosa PAO1 quorum sensing (QS) mechanisms, which are key regulators of virulence factor expression and implicated in biofilm formation. One of the active compounds has been is... |
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Effect of selective decontamination on antimicrobial resistance in intensive care units: a systematic review and meta-analysis.
Lancet Infect. Dis. 13(4) , 328-41, (2013) Many meta-analyses have shown reductions in infection rates and mortality associated with the use of selective digestive decontamination (SDD) or selective oropharyngeal decontamination (SOD) in intensive care units (ICUs). These interventions have not been w... |
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Mixed-mode liquid chromatography coupled to tandem mass spectrometry for the analysis of aminoglycosides in meat.
Anal. Bioanal. Chem 406(20) , 4941-53, (2014) A novel LC-MS/MS method has been developed for the determination of 13 aminoglycoside antibiotics in meat products. Among the chromatographic columns tested, the mixed-mode Obelisc R provided the best performance. Electrospray has been used for the coupling o... |
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Esculentin-1a(1-21)NH2: a frog skin-derived peptide for microbial keratitis.
Cell. Mol. Life Sci. 72(3) , 617-27, (2015) Pseudomonas aeruginosa is the primary bacterial pathogen causing contact lens related keratitis. Available ophthalmic agents have reduced efficacy and antimicrobial peptides (AMPs) hold promise as future antibiotics. Here we investigated the in vitro and in v... |
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Topical cyclosporine a 1% for the treatment of chronic ocular surface inflammation.
Eye Contact Lens 40(5) , 283-8, (2014) To evaluate the use of topical cyclosporine A (CsA) 1% emulsion in the treatment of chronic ocular surface inflammation (OSI).We conducted a retrospective chart review of patients with various forms of OSI treated with topical CsA 1% from 2001 to 2012.Twenty-... |
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Contralateral eye comparison of descemet membrane endothelial keratoplasty and descemet stripping automated endothelial keratoplasty.
Am. J. Ophthalmol. 159(1) , 155-9.e1, (2014) To compare objective and subjective outcomes after Descemet membrane endothelial keratoplasty (DMEK) and Descemet stripping automated endothelial keratoplasty (DSAEK) in the fellow eye of the same patients.Single-center, retrospective case series.Seventeen pa... |
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Role of C/EBP homologous protein in retinal ganglion cell death after ischemia/reperfusion injury.
Invest. Ophthalmol. Vis. Sci. 56(1) , 221-31, (2015) To investigate the role of C/EBP homologous protein (CHOP), a proapoptotic protein, and the unfolded protein response (UPR) marker that is involved in endoplasmic reticulum (ER) stress-mediated apoptosis in mouse retinal ganglion cell (RGC) death following is... |
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Cost-effectiveness of perioperative selective decontamination of the digestive tract versus placebo in elective gastrointestinal surgery.
Dig. Surg. 29(5) , 384-90, (2012) We compared the routine use of perioperative selective decontamination of the digestive tract (SDD) for elective gastrointestinal surgery with placebo in a randomized controlled trial. Alongside this trial, a cost-effectiveness analysis from a provider perspe... |
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Effects of decontamination of the digestive tract and oropharynx in intensive care unit patients on 1-year survival.
Am. J. Respir. Crit. Care Med. 188(1) , 117-20, (2013)
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