Amikacin
Amikacin structure
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Common Name | Amikacin | ||
|---|---|---|---|---|
| CAS Number | 37517-28-5 | Molecular Weight | 585.602 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 981.8±65.0 °C at 760 mmHg | |
| Molecular Formula | C22H43N5O13 | Melting Point | 203-204ºC (sesquihydrate) | |
| MSDS | N/A | Flash Point | 547.6±34.3 °C | |
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Enhancement of in vitro activity of tuberculosis drugs by addition of thioridazine is not reflected by improved in vivo therapeutic efficacy.
Tuberculosis (Edinb.) 94(6) , 701-7, (2015) Assessment of the activity of thioridazine towards Mycobacterium tuberculosis (Mtb), in vitro and in vivo as a single drug and in combination with tuberculosis (TB) drugs.The in vitro activity of thioridazine as single drug or in combination with TB drugs was... |
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Aminoglycosides suppress the protein folding activity of the molecular chaperone HSC70: implication of a structure-activity relationship.
Chemotherapy 60(1) , 37-46, (2014) The mechanism of aminoglycoside (AG)-induced nephrotoxicity has not been fully elucidated. We previously reported that gentamicin suppresses the functions of HSC70, a heat shock cognate protein, which is a cytosolic molecular chaperone in mammalian cells. How... |
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Phenotypic heterogeneity enables uropathogenic Escherichia coli to evade killing by antibiotics and serum complement.
Infect. Immun. 83(3) , 1056-67, (2015) Uropathogenic strains of Escherichia coli (UPEC) are the major cause of bacteremic urinary tract infections. Survival in the bloodstream is associated with different mechanisms that help to resist serum complement-mediated killing. While the phenotypic hetero... |
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In vitro performance of spacers for aerosol delivery during adult mechanical ventilation.
J. Aerosol Med. Pulm. Drug Deliv. 28(2) , 130-6, (2015) During mechanical ventilation, different aerosol generators are employed with various interfaces. The objective of this study was to evaluate the performance of a range of spacers, including a new device called Combihaler® designed for connection with both ne... |
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Comparative study of the effects of antituberculosis drugs and antiretroviral drugs on cytochrome P450 3A4 and P-glycoprotein.
Antimicrob. Agents Chemother. 58(6) , 3168-76, (2014) Predicting drug-drug interactions (DDIs) related to cytochrome P450 (CYP), such as CYP3A4 and one of the major drug transporters, P-glycoprotein (P-gp), is crucial in the development of future chemotherapeutic regimens to treat tuberculosis (TB) and TB/AIDS c... |
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Safety and technological characterization of Staphylococcus equorum isolates from jeotgal, a Korean high-salt-fermented seafood, for starter development.
Int. J. Food Microbiol. 188 , 108-15, (2014) To select starters for jeotgal, a traditional Korean high-salt-fermented seafood, the safety and technological properties of its predominant bacteria isolates, which were identified as Staphylococcus equorum, were assessed. Among the 185 S. equorum isolates f... |
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Aminoglycoside-mediated relaxation of the ductus arteriosus in sepsis-associated PDA.
Am. J. Physiol. Heart Circ. Physiol. 307(5) , H732-40, (2014) Sepsis is strongly associated with patency of the ductus arteriosus (PDA) in critically ill newborns. Inflammation and the aminoglycoside antibiotics used to treat neonatal sepsis cause smooth muscle relaxation, but their contribution to PDA is unknown. We ex... |
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Efflux pump gene expression in multidrug-resistant Mycobacterium tuberculosis clinical isolates.
PLoS ONE 10(2) , e0119013, (2015) Isoniazid (INH) and rifampicin (RIF) are the two most effective drugs in tuberculosis therapy. Understanding the molecular mechanisms of resistance to these two drugs is essential to quickly diagnose multidrug-resistant (MDR) tuberculosis and extensive drug-r... |
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Bacteriological characterization of a Mycobacterium parascrofulaceum strain isolated from a Chinese pneumonia patient.
Int. J. Infect. Dis. 25 , 82-7, (2014) A Mycobacterium parascrofulaceum strain was isolated from a pneumonia patient-the first such reported case from China. The bacteriological characteristics of the strain were determined.Species identification was performed by homologue gene sequence comparison... |
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Incidence and risk factors for extensively drug-resistant tuberculosis in Delhi region.
PLoS ONE 8(2) , e55299, (2013) India with a major burden of multidrug-resistant tuberculosis (MDR-TB) does not have national level data on this hazardous disease. Since 2006, emergence of extensively drug-resistant TB (XDR-TB) is considered a serious threat to global TB control. This study... |