Complement factor D
Complement factor D structure
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Common Name | Complement factor D | ||
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| CAS Number | 37213-56-2 | Molecular Weight | N/A | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | N/A | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
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Structures of native and complexed complement factor D: implications of the atypical His57 conformation and self-inhibitory loop in the regulation of specific serine protease activity.
J. Mol. Biol. 282 , 1061-1081, (1998) Factor D is a serine protease essential for the activation of the alternative pathway of complement. The structures of native factor D and a complex formed with isatoic anhydride inhibitor were determined at resolution of 2.3 and 1.5 A, respectively, in an is... |
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Immune evasion of Enterococcus faecalis by an extracellular gelatinase that cleaves C3 and iC3b.
J. Histochem. Cytochem. 181 , 6328-36, (2008) Enterococcus faecalis (Ef) accounts for most cases of enterococcal bacteremia, which is one of the principal causes of nosocomial bloodstream infections (BSI). Among several virulence factors associated with the pathogenesis of Ef, an extracellular gelatinase... |
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Complement factor D in age-related macular degeneration.
Invest. Ophthalmol. Vis. Sci. 52 , 8828-8834, (2011) To examine the role of complement factor D (CFD) in age-related macular degeneration (AMD) by analysis of genetic association, copy number variation, and plasma CFD concentrations.Single nucleotide polymorphisms (SNPs) in the CFD gene were genotyped and the r... |
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The use of monoclonal antibodies as probes of the three-dimensional structure of human complement factor D.
J. Immunol. 132 , 809, (1984) The monoclonal antibodies (MAb) were studied for their binding specificities and their effects on the hemolytic and proteolytic activities of human D. One Mab, FD10-1, was obtained from mice immunized with native D; the other, JA4-2, was similarly obtained fr... |
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Lack of association of CFD polymorphisms with advanced age-related macular degeneration.
Mol. Vis. 16 , 2273-2278, (2010) Age-related macular degeneration (AMD) is the most common cause of irreversible central vision loss worldwide. Research has linked AMD susceptibility with dysregulation of the complement cascade. Typically, complement factor H (CFH), complement factor B (CFB)... |