Pandinotoxin Kα
Pandinotoxin Kα structure
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Common Name | Pandinotoxin Kα | ||
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| CAS Number | 185529-64-0 | Molecular Weight | 4033.71 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C169H267N53O48S7 | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
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Three new toxins from the scorpion Pandinus imperator selectively block certain voltage-gated K+ channels.
Mol. Pharmacol. 50 , 1167-1177, (1996) Three 35-amino acid peptide K+ channel toxins (pandinotoxins) were purified from the venom of the scorpion Pandinus imperaton the toxins are designated pandinotoxin (PiTX)-K alpha, PiTX-K beta, and PiTX-K gamma. In an 86Rb tracer flux assay on rat brain synap... |
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Scorpion toxin block of the early K+ current (IKf) in rat dorsal root ganglion neurones.
J. Physiol. 503 2 , 285-301, (1997) 1. The ability of three structurally homologous scorpion toxins to block voltage-dependent K+ currents in rat dorsal root ganglion neurones was examined using the patch-clamp technique. 2. Neurones with a diameter > 35 microns had two identifiable components ... |
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Solution structure for Pandinus toxin K-alpha (PiTX-K alpha), a selective blocker of A-type potassium channels.
Biochemistry 36 , 2763-2771, (1997) PiTX-K alpha, a 35-residue peptide recently isolated from the venom of Pandinus imperator, blocks the rapidly inactivating (A-type) K+ channel(s) in rat brain synaptosomes and the cloned Kv 1.2 potassium channel at very low toxin concentrations (6 nM and 32 p... |