SB 204070
SB 204070 structure
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Common Name | SB 204070 | ||
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| CAS Number | 148702-58-3 | Molecular Weight | 419.34 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C19Cl1H27N2O4 | Melting Point | 243-245 °C(lit.) | |
| MSDS | USA | Flash Point | N/A | |
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Subepithelial trypsin induces enteric nerve-mediated anion secretion by activating proteinase-activated receptor 1 in the mouse cecum.
J. Physiol. Sci. 62(3) , 211-9, (2012) Serine proteases are versatile signaling molecules and often exert this function by activating the proteinase-activated receptors (PAR(1)-PAR(4)). Our previous study on the mouse cecum has shown that the PAR(1)-activating peptide (AP) and PAR(2)-AP both induc... |
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Evidence for 5-HT7 receptors mediating relaxation of human colonic circular smooth muscle.
Br. J. Pharmacol. 128(4) , 849-52, (1999) 5-HT4 receptors mediate relaxation of human colon circular muscle. However, after 5-HT4 receptor blockade (SB 204070 10 nM), 5-HT still induced a relaxation (pEC50 6.3). 5-HT4 receptors were sufficiently blocked, as the curves to 5-HT obtained in the presence... |
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The effects of SB 204070, a highly potent and selective 5-HT4 receptor antagonist, on guinea-pig distal colon.
Br. J. Pharmacol. 112(3) , 789-94, (1994) 1. The pharmacology of a novel 5-HT4 receptor antagonist, SB 204070 has been evaluated in the guinea-pig isolated distal colon longitudinal muscle-myenteric plexus (LMMP). 2. SB 204070 is a highly potent antagonist of 5-HT-evoked cholinergically-mediated cont... |
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Peripheral 5-HT4 receptors.
FASEB J. 10(12) , 1398-407, (1996) The 5-HT4 receptor is a member of the seven transmembrane spanning G-protein-coupled family of receptors. The receptor is positively coupled to adenylate cyclase and exists in two isoforms (5-HT4S and 5-HT4L) that differ in the length and sequence of their ca... |
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Pharmacological characterization of the human 5-HT(4(d)) receptor splice variant stably expressed in Chinese hamster ovary cells.
Br. J. Pharmacol. 131 , 827, (2000) The recently identified C-terminal splice variant of the human 5-HT(4) receptor, the h5-HT(4(d)) receptor, was stably expressed in a CHO cell line at 493+/-25 fmol mg(-1) protein. We analysed its pharmacological properties by measuring binding affinities and ... |
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(1-Butyl-4-piperidinyl)methyl 8-amino-7-chloro-1,4-benzodioxane-5-carboxylate hydrochloride: a highly potent and selective 5-HT4 receptor antagonist derived from metoclopramide.
J. Med. Chem. 36 , 4121, (1993)
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