LIPID A, DIPHOSPHORYL FROM ESCHERICHIA COLI F-583 (RD MUTANT)
LIPID A, DIPHOSPHORYL FROM ESCHERICHIA COLI F-583 (RD MUTANT) structure
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Common Name | LIPID A, DIPHOSPHORYL FROM ESCHERICHIA COLI F-583 (RD MUTANT) | ||
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| CAS Number | 95991-05-2 | Molecular Weight | 177.975082 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | H4O7P2 | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
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Structural requirements of lipid A for endotoxicity and other biological activities.
Crit. Rev. Microbiol 16 , 477-523, (1989) For the past ten years, several groups were engaged in synthetic studies of lipid A, namely the lipid portion of bacterial lipopolysaccharides (LPS) that has been assumed to be the bioactive center of LPS, but has not been unanimously approved. Among them, Sh... |
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Structure of bacterial lipopolysaccharides.
Carbohydr. Res. 338 , 2431-2447, (2003) Bacterial lipopolysaccharides are the major components of the outer surface of Gram-negative bacteria They are often of interest in medicine for their immunomodulatory properties. In small amounts they can be beneficial, but in larger amounts they may cause e... |
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Structural analysis of lipopolysaccharides from Gram-negative bacteria.
Biochemistry. (Mosc.) 75 , 383-404, (2010) This review covers data on composition and structure of lipid A, core, and O-polysaccharide of the known lipopolysaccharides from Gram-negative bacteria. The relationship between the structure and biological activity of lipid A is discussed. The data on roles... |
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Structure-activity relationship of chemically synthesized nonreducing parts of lipid A analogs.
Adv. Exp. Med. Biol. 256 , 101-109, (1990) Some synthetic compounds of the nonreducing part of lipid A were found to preserve significant immunopharmacological activities of the endotoxin, at the same time showing very slight if any endotoxic activity such as pyrogenicity lethality or Shwartzman react... |
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The attenuated inflammation of MPL is due to the lack of CD14-dependent tight dimerization of the TLR4/MD2 complex at the plasma membrane.
Int. Immunol. 26(6) , 307-14, (2014) TLR4/MD-2 senses lipid A, activating the MyD88-signaling pathway on the plasma membrane and the TRIF-signaling pathway after CD14-mediated TLR4/MD-2 internalization into endosomes. Monophosphoryl lipid A (MPL), a detoxified derivative of lipid A, is weaker th... |