ISPA-28
ISPA-28 structure
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Common Name | ISPA-28 | ||
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| CAS Number | 1006335-39-2 | Molecular Weight | 408.454 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C21H24N6O3 | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
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An epigenetic antimalarial resistance mechanism involving parasite genes linked to nutrient uptake.
J. Biol. Chem. 288(27) , 19429-40, (2013) Acquired antimalarial drug resistance produces treatment failures and has led to periods of global disease resurgence. In Plasmodium falciparum, resistance is known to arise through genome-level changes such as mutations and gene duplications. We now report a... |
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Malaria parasite mutants with altered erythrocyte permeability: a new drug resistance mechanism and important molecular tool.
Future Microbiol. 5(1) , 81-97, (2010) Erythrocytes infected with plasmodia, including those that cause human malaria, have increased permeability to a diverse collection of organic and inorganic solutes. While these increases have been known for decades, their mechanistic basis was unclear until ... |
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