Aspartame
Aspartame structure
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Common Name | Aspartame | ||
|---|---|---|---|---|
| CAS Number | 22839-47-0 | Molecular Weight | 294.303 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 535.8±50.0 °C at 760 mmHg | |
| Molecular Formula | C14H18N2O5 | Melting Point | 242-248 °C | |
| MSDS | Chinese USA | Flash Point | 277.8±30.1 °C | |
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Determination of eight artificial sweeteners and common Stevia rebaudiana glycosides in non-alcoholic and alcoholic beverages by reversed-phase liquid chromatography coupled with tandem mass spectrometry.
Anal. Bioanal. Chem 407(5) , 1505-12, (2015) The method for the determination of acesulfame-K, saccharine, cyclamate, aspartame, sucralose, alitame, neohesperidin dihydrochalcone, neotame and five common steviol glycosides (rebaudioside A, rebaudioside C, steviol, steviolbioside and stevioside) in soft ... |
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Artificial sweeteners induce glucose intolerance by altering the gut microbiota.
Nature , doi:10.1038/nature13793, (2014) Non-caloric artificial sweeteners (NAS) are among the most widely used food additives worldwide, regularly consumed by lean and obese individuals alike. NAS consumption is considered safe and beneficial owing to their low caloric content, yet supporting scien... |
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Modulation of sweet taste by umami compounds via sweet taste receptor subunit hT1R2.
PLoS ONE 10(4) , e0124030, (2015) Although the five basic taste qualities-sweet, sour, bitter, salty and umami-can be recognized by the respective gustatory system, interactions between these taste qualities are often experienced when food is consumed. Specifically, the umami taste has been i... |
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Low-calorie sweeteners in food and food supplements on the Italian market.
Food. Addit. Contam. Part. B. Surveill. 8 , 298-308, (2015) This study determines the occurrence and concentration levels of artificial low-calorie sweeteners (LCSs) in food and food supplements on the Italian market. The analysed sample set (290 samples) was representative of the Italian market and comprised of bever... |
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Hydrophilic interaction liquid chromatography coupled to high-resolution mass spectrometry to determine artificial sweeteners in environmental waters.
Anal. Bioanal. Chem 407 , 4277-85, (2015) Artificial sweeteners are food additives employed as sugar substitutes which are now considered to be emerging organic contaminants. In the present study, a method is developed for the determination of a group of artificial sweeteners in environmental waters.... |
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Trace-level determination of sweeteners in sewage sludge using selective pressurized liquid extraction and liquid chromatography-tandem mass spectrometry.
J. Chromatogr. A. 1408 , 15-21, (2015) The occurrence of sweeteners in the environment has become a matter of concern due to the possibility of adverse effects on human health and wildlife species. One of the routes by which sweeteners enter the environment is through sewage sludge. Therefore, a m... |
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Formulation strategy and evaluation of nanocrystal piroxicam orally disintegrating tablets manufacturing by freeze-drying.
Int. J. Pharm. 467(1-2) , 27-33, (2014) Piroxicam (PRX) is a non-steroidal anti-inflammatory drug characterized by a poor water solubility and consequently by a low oral bioavailability. In this work, different nanocrystal orally disintegrating tablets (ODT) were prepared to enhance piroxicam disso... |
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Stimulation of the extracellular Ca²⁺-sensing receptor by denatonium.
Biochem. Biophys. Res. Commun. 416(3-4) , 433-6, (2011) The extracellular Ca(2+)-sensing receptor (CASR) is a promiscuous G-protein-coupled receptor closely related to the taste receptors T1R1-T1R3. Here we analyzed the possibility that apart from being stimulated by external Ca(2+) and amino acids, the substances... |
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Clinical safety of aspartame.
Am. Fam. Physician 39(2) , 201-6, (1989) Aspartame is a synthetic sweetener commonly used in soft drinks and many foods. Even with high doses, the metabolites of this sweetener do not accumulate in toxic amounts. To date, no definite symptom complex has been connected with aspartame, and it is consi... |
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Studies on the effects of aspartame on memory and oxidative stress in brain of mice.
Eur. Rev. Med. Pharmacol. Sci. 16(15) , 2092-101, (2012) The dipeptide aspartame (N-L-alpha-aspartyl-Lphenylalanine, 1-methyl ester; alpha-APM) is one of the most widely used artificial sweeteners. The present study aimed to investigate the effect of repeated administration of aspartame in the working memory versio... |