Plasminogen
Plasminogen structure
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Common Name | Plasminogen | ||
|---|---|---|---|---|
| CAS Number | 9001-91-6 | Molecular Weight | 226.232 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 656.2±55.0 °C at 760 mmHg | |
| Molecular Formula | C9H14N4O3 | Melting Point | N/A | |
| MSDS | USA | Flash Point | 350.7±31.5 °C | |
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Hemoglobin promotes Staphylococcus aureus nasal colonization.
PLoS Pathog. 7 , e1002104, (2011) Staphylococcus aureus nasal colonization is an important risk factor for community and nosocomial infection. Despite the importance of S. aureus to human health, molecular mechanisms and host factors influencing nasal colonization are not well understood. To ... |
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Effects of black cohosh on the plasminogen activator system in vascular smooth muscle cells.
Maturitas 76(1) , 75-80, (2013) The rhizome of the Cimicifuga racemosa plant (commonly known as black cohosh) has been used for menopausal complaints. Studies regarding the cardiovascular effects of black cohosh are lacking. We investigated the effect of black cohosh on the plasminogen acti... |
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Potent fibrinolysis inhibitor discovered by shape and electrostatic complementarity to the drug tranexamic acid.
J. Med. Chem. 56(8) , 3273-80, (2013) Protein-protein interfaces provide an important class of drug targets currently receiving increased attention. The typical design strategy to inhibit protein-protein interactions usually involves large molecules such as peptides and macrocycles. One exception... |
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Diabetes is associated with posttranslational modifications in plasminogen resulting in reduced plasmin generation and enzyme-specific activity.
Blood 122(1) , 134-42, (2013) Diabetes is associated with hypofibrinolysis by mechanisms that are only partially understood. We investigated the effects of in vivo plasminogen glycation on fibrinolysis, plasmin generation, protein proteolytic activity, and plasminogen-fibrin interactions.... |
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Gender affects skin wound healing in plasminogen deficient mice.
PLoS ONE 8(3) , e59942, (2013) The fibrinolytic activity of plasmin plays a fundamental role in resolution of blood clots and clearance of extravascular deposited fibrin in damaged tissues. These vital functions of plasmin are exploited by malignant cells to accelerate tumor growth and fac... |
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Surface associated antigens of Dirofilaria immitis adult worms activate the host fibrinolytic system.
Vet. Parasitol. 196(1-2) , 235-40, (2013) Cardiopulmonary dirofilariosis (Dirofilaria immitis) is characterized by apparent contradictory events, like the long-term survival of adult worms in the circulatory system of the infected hosts and the development of life-threatening events like thromboembol... |
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Proteolytic modulation of factor Xa–antithrombin complex enhances fibrinolysis in plasma
Biochim. Biophys. Acta 1834(6) , 989-95, (2013) Our previous work showed that purified coagulation factor Xa (FXa) acquires fibrinolysis cofactor activity after plasmin-mediated cleavage. The predominant functional species is a non-covalent heterodimer of 33 and 13kDa, termed Xa33/13, which has predicted n... |
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Macrophage gene expression and foam cell formation are regulated by plasminogen.
Circulation 127(11) , 1209-18, e1-16, (2013) Deciphering the molecular and cellular processes that govern macrophage foam cell formation is critical to understanding the basic mechanisms underlying atherosclerosis and other vascular pathologies.Here, we identify a pivotal role of plasminogen (Plg) in re... |
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Thrombomodulin functions as a plasminogen receptor to modulate angiogenesis.
FASEB J. 27(11) , 4520-31, (2013) Urokinase-type plasminogen activator (uPA) activates plasminogen (Plg) through a major pericellular proteolytic system involved in cell migration and angiogenesis; however, the Plg receptor that participates in uPA-mediated Plg activation has not yet been ide... |
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Characterization of three novel adhesins of Leptospira interrogans.
Am. J. Trop. Med. Hyg. 89(6) , 1103-16, (2013) We report cloning, expression, purification, and characterization of three predicted leptospiral membrane proteins (LIC11360, LIC11009, and LIC11975). In silico analysis and proteinase K accessibility data suggest that these proteins might be surface exposed.... |