ACTH (7-38) (human)
ACTH (7-38) (human) structure
|
Common Name | ACTH (7-38) (human) | ||
|---|---|---|---|---|
| CAS Number | 68563-24-6 | Molecular Weight | 3659.11 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C167H257N47O46 | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
|
Gastric inhibitory polypeptide stimulates glucocorticoid secretion in rats, acting through specific receptors coupled with the adenylate cyclase-dependent signaling pathway.
Peptides 20(5) , 589-94, (1999) Gastric inhibitory polypeptide (GIP) is a 42-amino acid peptide, belonging to the VIP-secretin-glucagon superfamily, some members of this group are able to regulate adrenocortical function. GIP-receptor mRNA has been detected in the rat adrenal cortex, but in... |
|
|
Evidence that an extrahypothalamic pituitary corticotropin-releasing hormone (CRH)/adrenocorticotropin (ACTH) system controls adrenal growth and secretion in rats.
Cell Tissue Res. 272(3) , 439-45, (1993) Within two weeks, hypophysectomy induced in rats a striking decrease in the level of circulating ACTH (the concentration of which was at the limit of sensitivity of our assay system), coupled with a net reduction in the plasma corticosterone concentration and... |
|
|
Adrenocorticotrophic hormone modulates Escherichia coli O157:H7 adherence to porcine colonic mucosa.
Stress 8(3) , 185-90, (2005) Exposure to stress is associated with susceptibility to disease and one stress mediator, norepinephrine, has been reported to enhance the adherence of enterohemorrhagic Escherichia coli O157:H7 (EHEC) to the colonic mucosa. We tested the hypothesis that adren... |
|
|
Synthetic modified N-POMC(1-28) controls in vivo proliferation and blocks apoptosis in rat adrenal cortex.
Cell Tissue Res. 341(2) , 239-50, (2010) The identity of the pro-opiomelanocortin (POMC)-derived mitogen in the adrenal cortex has been historically controversial. We have used well-established in vivo models, viz., hypophysectomized (Hyp) or dexamethasone (Dex)-treated rats, to study the effect of ... |
|
|
Multireaction monitoring of 12 peptides for lowered immunity screening.
Anal. Bioanal. Chem 404(8) , 2249-58, (2012) A multireaction monitoring method using high-performance liquid chromatography-tandem mass spectrometry was developed for 12 target peptides for determination of endogenous peptide concentrations in human serum. Chromatographic separation conditions were opti... |
|
|
Corticotropin-inhibiting peptide enhances aldosterone secretion by dispersed rat zona glomerulosa cells.
J. Steroid Biochem. Mol. Biol. 67(2) , 149-52, (1998) Corticotropin-inhibiting peptide (CIP), the 7-38 fragment of human ACTH(1-39), is known to act as an antagonist of ACTH receptors. Accordingly, CIP has been found to inhibit ACTH-stimulated glucocorticoid secretion of dispersed rat adrenocortical cells, witho... |
|
|
Vasoactive intestinal peptide stimulates rat adrenal glucocorticoid secretion, through an ACTH receptor-dependent activation of the adenylate cyclase signaling pathway.
Horm. Metab. Res. 30(5) , 241-3, (1998) Vasoactive intestinal peptide (VIP) concentration-dependently enhanced corticosterone and cyclic-AMP release by dispersed rat inner adrenocortical cells. A VIP-receptor antagonist and the ACTH-receptor antagonist corticotropin-inhibiting peptide annulled both... |
|
|
Inhibition of canine lung angiotensin converting enzyme by ACTH and structurally related peptides.
Biochem. Biophys. Res. Commun. 104(4) , 1484-8, (1982)
|
|
|
A novel endogenous corticotropin release inhibiting factor.
Ann. N. Y. Acad. Sci. 840 , 456-69, (1998) ACTH is the major regulator of the body's adaptive response to stress and the physiological stimulus for glucocorticoid secretion. A hypothalamic corticotropin release inhibiting factor (CRIF) that inhibits ACTH synthesis and secretion has long been postulate... |
|
|
Bacterial lipopolysaccharide stimulates glucocorticoid secretion in hypophysectomized rats.
Endocr. Res. 21(3) , 525-36, (1995) The effect of an i.p. bolus injection of 200 micrograms.kg-1 bacterial lipopolysaccharide (LPS) on the plasma concentrations of ACTH and corticosterone (B) were studied in intact and hypophysectomized/ACTH replaced (Hx) rats. Hormonal blood levels were measur... |