Z-Arg-Arg-Pro-Phe-His-Sta-Ile-His-Lys(Boc)-OMe
Z-Arg-Arg-Pro-Phe-His-Sta-Ile-His-Lys(Boc)-OMe structure
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Common Name | Z-Arg-Arg-Pro-Phe-His-Sta-Ile-His-Lys(Boc)-OMe | ||
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| CAS Number | 93287-54-8 | Molecular Weight | 1495.769 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C72H110N20O15 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
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Sustained reduction in blood pressure during chronic administration of a renin inhibitor to normotensive marmosets.
J. Cardiovasc. Pharmacol. 10 Suppl 7 , S96-8, (1987) In this study, the hypotensive efficacy of a renin inhibitor was investigated during chronic administration. The renin inhibitor CGP 29,287 was administered by continuous intraperitoneal infusion with osmotic mini-pumps to normotensive marmosets fed a low-sod... |
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Biochemical effects of prolonged renin inhibition in marmosets.
J. Hypertens. 7(8) , 615-8, (1989) The renin inhibitor CGP 29,287 was administered continuously for 7 days (30 mg/kg per day, intraperitoneally, via osmotic minipumps) to normotensive marmosets fed a low-salt diet. As a control, another group of marmosets was given vehicle only. After 7 days o... |
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Comparison of chronic inhibition of renin and converting enzyme in the marmoset.
Clin. Exp. Hypertens. A. 9(2-3) , 337-43, (1987) The primate-specific renin inhibitor CGP 29287 (30 mg/kg/d, n = 5) or the converting-enzyme inhibitor CGS 14831 (30 mg/kg/d, n = 8) were administered by continuous intraperitoneal infusion via osmotic minipumps to normotensive marmosets fed a low salt diet. C... |
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Renal vasodilatation after inhibition of renin or converting enzyme in marmoset.
Am. J. Physiol. 251(5 Pt 2) , H897-902, (1986) The relative importance of angiotensin II for the renal vasodilatory response after converting-enzyme inhibition was evaluated by a comparison of the effects of converting-enzyme and renin inhibition on renal vascular resistance. Renal, mesenteric, and hindqu... |
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Mechanism of inhibition of human renin by monoclonal antibodies.
Hypertension 11(3) , 209-16, (1988) The mechanism by which monoclonal antibodies directed against human renin (R3-36-16 and R3-47-10) inhibit renin activity was investigated using various substrates. Both antibodies acted as potent inhibitors of human renin activity when human angiotensinogen w... |
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Antihypertensive effect of a renin inhibitor in marmosets with a segmental renal infarction.
J. Hypertens. 5(6) , 721-5, (1987) Hypertension was induced in marmosets by ligating the minor branch of one renal artery. The blood pressure (BP), measured by a tail-cuff method, increased to hypertensive levels within 4-5 weeks and the maximum increases occurred after 4-15 weeks (BP, mean +/... |
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In vitro renin inhibition to prevent generation of angiotensins during determination of angiotensin I and II.
Life Sci. 42(17) , 1683-8, (1988) To prevent in vitro generation of angiotensins, the renin inhibitor CGP 29287 (CGP) was added to blood sampling tubes. Plasma immunoreactive angiotensin (ir-ANG) I and II were simultaneously measured by radioimmunoassay after rapid and quantitative extraction... |
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Expression of components of the RAS during prolonged blockade at different levels in primates.
Am. J. Physiol. 267(4 Pt 1) , E612-9, (1994) To assess the effects of inhibition of the renin-angiotensin system at different levels on plasma concentrations of components of the system and on renin and angiotensinogen gene expression, marmosets on a low-sodium diet were treated for 1 wk by continuous i... |
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Responses to renin inhibition in conscious primates.
Am. J. Physiol. 261(1 Pt 2) , F179-86, (1991) A method for the measurement of renal clearances was adapted in a novel manner to the conscious marmoset. Twenty-four hours before an experiment, animals underwent surgery for placement of both femoral arterial and venous catheters. A catheter was also implan... |
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Inhibition of renin-like activity in marmoset tissues by the renin inhibitor CGP 29 287.
J. Hypertens. Suppl. 5(2) , S67-9, (1987) This study investigated the contribution of tissue renin-like activity to the acute hypotensive response induced by the potent and specific inhibitor of primate renin, CGP 29 287. Furosemide-pretreated marmosets (5mg/kg, i.m.) were killed 30 min after bolus i... |