Pancreatic Polypeptide (rat)
Pancreatic Polypeptide (rat) structure
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Common Name | Pancreatic Polypeptide (rat) | ||
|---|---|---|---|---|
| CAS Number | 90419-12-8 | Molecular Weight | 4398.93 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C195H298N58O57S | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
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Non-specific binding and general cross-reactivity of Y receptor agonists are correlated and should importantly depend on their acidic sectors.
Peptides 32 , 258-265, (2011) Non-specific binding of Y receptor agonists to intact CHO cells, and to CHO cell or rat brain particulates, is much greater for human neuropeptide Y (hNPY) compared to porcine peptide Y (pPYY), and especially relative to human pancreatic polypeptide (hPP). Th... |
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Critical role of arcuate Y4 receptors and the melanocortin system in pancreatic polypeptide-induced reduction in food intake in mice.
PLoS ONE 4 , e8488, (2009) Pancreatic polypeptide (PP) is a potent anti-obesity agent known to inhibit food intake in the absence of nausea, but the mechanism behind this process is unknown.Here we demonstrate that in response to i.p. injection of PP in wild type but not in Y4 receptor... |
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Y4 receptors and pancreatic polypeptide regulate food intake via hypothalamic orexin and brain-derived neurotropic factor dependent pathways.
Neuropeptides 44 , 261-268, (2010) Gut-derived peptides are known to regulate food intake by activating specific receptors in the brain, but the target nuclei and neurons influenced are largely unknown. Here we show that peripherally administered pancreatic polypeptide (PP) stimulates neurons ... |
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Neuropeptide Y receptors; antisecretory control of intestinal epithelial function.
Auton. Neurosci. 133 , 76-85, (2007) This paper reviews the cellular localisation, mechanisms of release and intestinal absorptive actions of neuropeptide Y and its related peptides, peptide YY, pancreatic polypeptide and major fragments NPY(3-36) and PYY(3-36). While NPY is commonly found in in... |
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Pancreatic polypeptide enhances colonic muscle contraction and fecal output through neuropeptide Y Y4 receptor in mice.
Eur. J. Pharmacol. 627 , 258-264, (2010) Pancreatic polypeptide is released mainly from the pancreas, and is thought to be one of the major endogenous agonists of the neuropeptide Y Y(4) receptor. Pancreatic polypeptide has been shown to stimulate colonic muscle contraction, but whether pancreatic p... |
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Immunohistochemical localization of glucagon and pancreatic polypeptide on rat endocrine pancreas: coexistence in rat islet cells.
Eur. J. Histochem. 53 , 81-5, (2009) We used immunofluorescence double staining method to investigate the cellular localization of glucagon and pancreatic polypeptide (PP) in rat pancreatic islets. The results showed that both A-cells (glucagon-secreting cells) and PP-cells (PP-secreting cells) ... |