GHRF
GHRF structure
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Common Name | GHRF | ||
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| CAS Number | 86472-71-1 | Molecular Weight | 5232.89 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C225H360N76O67S | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
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Semisynthesis of human growth hormone-releasing factor by trypsin catalyzed coupling of leucine amide to a C-terminal acid precursor.
Int. J. Pept. Protein Res. 40(3-4) , 268-73, (1992) Human growth hormone-releasing factor, GRF(1-44)-NH2, was synthesized by trypsin catalyzed coupling of Leu-NH2 to Arg43 of the precursor, GRF(1-43)-OH, prepared by solid phase peptide synthesis. The semisynthetic GRF(1-44)-NH2 was fully characterized and show... |
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Characterization of rat hypothalamic growth hormone-releasing factor.
Nature 303 , 532-535, (1983) The importance of the hypothalamus in the regulation of growth hormone (GH) secretion from the adenohypophysis has been supported by experimental and clinical evidence. It has been observed that GH secretion is in part controlled by hypothalamic GH release-in... |
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Increased sensitivity of adipose tissue to insulin after in vivo treatment of yellow Avy/A obese mice with amino-terminal peptides of human growth hormone.
Endocrinology 122(6) , 2940-5, (1988) Treatment of obese yellow Avy/A mice with the human GH (hGH) peptide hGH-(1-43) enhanced the in vitro sensitivity of their adipose tissue to insulin. Insulin-stimulated glucose oxidation, as determined by measurement of 14CO2 production, was enhanced 106% aft... |
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Long-term maintenance of growth hormone secretion in perifused rat anterior pituitary cells.
Regul. Pept. 20(3) , 261-71, (1988) We studied the effect of rat growth hormone-releasing factor-(1-43) acid, rGRF(1-43)OH, on the long-term secretion of rat growth hormone (rGH) in dispersed primary cultured cells of rat anterior pituitaries over a period of 7 days or longer. Results of the pe... |
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Levels of human and rat hypothalamic growth hormone-releasing factor as determined by specific radioimmunoassay systems.
Proc. Natl. Acad. Sci. U. S. A. 82(9) , 2970-4, (1985) Polyclonal antibodies to synthetic human pancreatic growth hormone-releasing factor [hpGRF(1-44)NH2] and rat hypothalamic growth hormone-releasing factor [rhGRF(1-43)OH] were produced in rabbits by injecting these weak immunogens, coupled to thyroglobulin and... |
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A comparison of the biological activities of authentic rat GRF(1-43)OH with the analogue rat GRF(1-29)NH2.
Can. J. Physiol. Pharmacol. 69(2) , 181-4, (1991) The purpose of this study was to characterize the biological activity of the synthetic rat growth hormone releasing factor analogue rGRF(1-29)NH2 and to compare its action on growth hormone (GH) release to that of authentic rGRF(1-43)OH. We first compared the... |