Complement C3
Complement C3 structure
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Common Name | Complement C3 | ||
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| CAS Number | 80295-41-6 | Molecular Weight | N/A | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | N/A | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
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Immune evasion of Enterococcus faecalis by an extracellular gelatinase that cleaves C3 and iC3b.
J. Histochem. Cytochem. 181 , 6328-36, (2008) Enterococcus faecalis (Ef) accounts for most cases of enterococcal bacteremia, which is one of the principal causes of nosocomial bloodstream infections (BSI). Among several virulence factors associated with the pathogenesis of Ef, an extracellular gelatinase... |
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Complement C3 deficiency: human, animal, and experimental models.
Pathobiology 62 , 14-28, (1994) The third complement component (C3) is a multifunctional glycoprotein that interacts with numerous serum proteins, cell surface receptors, and membrane-associated regulatory proteins. Deficiencies of C3 have been reported in several human kindred of different... |
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Group A streptococcal cysteine protease degrades C3 (C3b) and contributes to evasion of innate immunity.
J. Biol. Chem. 283 , 6253-6260, (2008) A relative lack of neutrophils around Streptococcus pyogenes is observed in streptococcal toxic shock syndrome (STSS). Because the bacteria spread rapidly into various organs in STSS, we speculated that S. pyogenes is equipped with molecules to evade the host... |
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The role of complement and complement receptors in induction and regulation of immunity.
Annu. Rev. Immunol. 16 , 545-568, (1998) Covalent attachment of activated complement C3 (C3d) to antigen links innate and adaptive immunity by targeting antigen to follicular dendritic cells (FDC) and B cells via specific receptors CD21 and CD35. Recent characterization of knockout mice deficient in... |
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Tyrosines of human and mouse transferrin covalently labeled by organophosphorus agents: a new motif for binding to proteins that have no active site serine.
Toxicol. Pathol. 107 , 144-55, (2009) The expectation from the literature is that organophosphorus (OP) agents bind to proteins that have an active site serine. However, transferrin, a protein with no active site serine, was covalently modified in vitro by 0.5mM 10-fluoroethoxyphosphinyl-N-biotin... |
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Degradation of complement 3 by streptococcal pyrogenic exotoxin B inhibits complement activation and neutrophil opsonophagocytosis.
Infect. Immun. 76 , 1163-1169, (2008) Streptococcal pyrogenic exotoxin B (SPE B), a cysteine protease, is an important virulence factor in group A streptococcus (GAS) infection. The inhibition of phagocytic activity by SPE B may help prevent bacteria from being ingested. In this study, we examine... |