Ganglioside GM2 Mixture (bovine brain) (ammonium salt)
Ganglioside GM2 Mixture (bovine brain) (ammonium salt) structure
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Common Name | Ganglioside GM2 Mixture (bovine brain) (ammonium salt) | ||
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| CAS Number | 19600-01-2 | Molecular Weight | 1384.682 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 1417.9±65.0 °C at 760 mmHg | |
| Molecular Formula | C67H121N3O26 | Melting Point | N/A | |
| MSDS | USA | Flash Point | 811.3±34.3 °C | |
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Altered levels of α-synuclein and sphingolipids in Batten disease lymphoblast cells.
Gene 539(2) , 181-5, (2014) Batten disease (juvenile neuronal ceroid lipofuscinosis) is a neurodegenerative disorder characterized by blindness, seizures, cognitive decline, and early death due to the inherited mutation of the CLN3 gene. Although α-synuclein and sphingolipids are releva... |
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Ganglioside-embedding small bicelles for probing membrane-landing processes of intrinsically disordered proteins.
Chem. Commun. (Camb.) 49(12) , 1235-7, (2013) We successfully displayed a series of gangliosides on small bicelles with a uniform confined size, offering nanoscale standardized membrane mimics for spectroscopic characterization of weak encounter complexes formed between ganglioside clusters and amyloidog... |
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Use of carbohydrate-conjugated nanoparticles for an integrated approach to functional imaging of glycans and understanding of their molecular mechanisms.
Curr. Pharm. Biotechnol. 13(14) , 2612-6, (2012) Functional analysis of carbohydrates is needed to understand the initial interface between membranes and the outer world. For this analysis we need individual protocols such as a method to modify the surfaces of nanoparticles with a variety of carbohydrates e... |
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Abnormal gangliosides are localized in lipid rafts in Sanfilippo (MPS3a) mouse brain.
Neurochem. Res. 37(6) , 1372-80, (2012) Allogenic stem cell transplantation can reduce lysosomal storage of heparan sulfate-derived oligosaccharides by up to 27 % in Sanfilippo MPS3a brain, but does not reduce the abnormal storage of sialolactosylceramide (G(M3)) or improve neurological symptoms, s... |
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Therapeutic effects of stem cells and substrate reduction in juvenile Sandhoff mice.
Neurochem. Res. 37(6) , 1335-43, (2012) Sandhoff Disease (SD) involves the CNS accumulation of ganglioside GM2 and asialo-GM2 (GA2) due to inherited defects in the β-subunit gene of β-hexosaminidase A and B (Hexb gene). Substrate reduction therapy, utilizing imino sugar N-butyldeoxygalactonojirimyc... |
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Characterization of inducible models of Tay-Sachs and related disease.
PLoS Genet. 8(9) , e1002943, (2012) Tay-Sachs and Sandhoff diseases are lethal inborn errors of acid β-N-acetylhexosaminidase activity, characterized by lysosomal storage of GM2 ganglioside and related glycoconjugates in the nervous system. The molecular events that lead to irreversible neurona... |
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Molecular and biochemical characterization of a novel β-N-acetyl-D-hexosaminidase with broad substrate-spectrum from the Aisan corn borer, Ostrinia furnacalis.
Int. J. Biol. Sci. 8(8) , 1085-96, (2012) Insect β-N-acetyl-D-hexosaminidases with broad substrate-spectrum (IBS-Hex) are the homologues of human β-N-acetyl-D-hexosaminidase A/B (HsHex A/ B). These enzymes are distributed in most insect species and vary in physiological roles. In this study, the gene... |
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Lyso-GM2 ganglioside: a possible biomarker of Tay-Sachs disease and Sandhoff disease.
PLoS ONE 6(12) , e29074, (2011) To find a new biomarker of Tay-Sachs disease and Sandhoff disease. The lyso-GM2 ganglioside (lyso-GM2) levels in the brain and plasma in Sandhoff mice were measured by means of high performance liquid chromatography and the effect of a modified hexosaminidase... |
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Acquired infantile abducens palsy associated with anti-GM2 antibodies.
Pediatr. Neurol. 44(6) , 459-62, (2011) Anti-ganglioside antibodies have been associated with acquired neuropathies, including Guillain-Barré syndrome. We describe a case of acute abducens nerve palsy acquired 2 weeks after symptoms of upper respiratory tract infection and rash in a 6-month-old. El... |
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The Sda/GM2-glycan is a carbohydrate marker of porcine primordial germ cells and of a subpopulation of spermatogonia in cattle, pigs, horses and llama.
Reproduction 142(5) , 667-74, (2011) Spermatogonia are a potential source of adult pluripotent stem cells and can be used for testis germ cell transplantation. Markers for the isolation of these cells are of great importance for biomedical applications. Primordial germ cells and prepubertal sper... |