Sarafotoxin S6b
Sarafotoxin S6b structure
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Common Name | Sarafotoxin S6b | ||
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| CAS Number | 116303-65-2 | Molecular Weight | 2563.925 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 2570.1±65.0 °C at 760 mmHg | |
| Molecular Formula | C110H159N27O34S5 | Melting Point | N/A | |
| MSDS | USA | Flash Point | 1508.1±34.3 °C | |
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Sarafotoxin, a novel vasoconstrictor peptide: phosphoinositide hydrolysis in rat heart and brain.
Science 242 , 268, (1988) Sarafotoxins, a group of 21-residue cardiotoxic peptides from snake venom that induce coronary vasoconstriction, show high-affinity binding to rat atrial and brain membranes and activate the hydrolysis of phosphoinositides. Neither their binding nor their act... |
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Sarafotoxins S6: several isotoxins from Atractaspis engaddensis (burrowing asp) venom that affect the heart.
Toxicon 26 , 543, (1988) Three isotoxins, named sarafotoxins S6a1, S6b and S6c, with strong cardiotoxic activity were isolated from the venom of a snake, Atractaspis engaddensis. All three sarafotoxins are homologous peptides (four or less than four residue replacements) consisting o... |
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Role of the endothelin axis and its antagonists in the treatment of cancer.
Br. J. Pharmacol. 163 , 220-233, (2011) The endothelins (ET) are a group of proteins that act through G-protein coupled receptors. Endothelin-1 (ET-1) was initially identified as a potent vasoconstrictor and dysregulation of the ET axis contributes to pathological processes responsible for cardiova... |
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LPS fromPorphyromonas gingivalisincreases the sensitivity of contractile response mediated by endothelin-B (ETB) receptors in cultured endothelium-intact rat coronary arteries
Vascul. Pharmacol. 53 , 250-257, (2010) The purpose of our study was to examine if lipopolysaccharide (LPS) from Porphyromonas gingivalis ( P.g.) modifies the vasomotor responses to Endothelin-1 (ET-1) and Sarafotoxin 6c (S6c) in rat coronary arteries. The arteries were studied directly or followin... |
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Functional and molecular characterization of the endothelin system in retinal arterioles.
Invest. Ophthalmol. Vis. Sci. 50 , 3329-3336, (2009) Activation of the endothelin (ET) system has been implicated in the pathogenesis of retinal ischemic disease. Although ET-1, the predominant endogenous isoform of ET, has been shown to cause constriction of retinal vessels, the expression and functional signi... |
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Endothelin ET(B) receptors in arteries and veins: multiple actions in the vein.
J. Pharmacol. Exp. Ther. 329 , 875-881, (2009) Endothelin receptors (ET(A) and ET(B)) mediate responses to ET-1. ET(B) receptor function seems to differ between a similarly sized arterial and venous pair, the rat vena cava (RVC) and rat thoracic aorta (RA). ET(B) receptors mediate RVC contraction directly... |
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Endothelin increases the ciliary beat frequency of ovine airway epithelium via its interaction with endothelin a receptors. Pawsey J, Lansley AB, Lethem MI.
Pulm. Pharmacol. 24 , 602-609, (2011)
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