Leptin (human), (recombinant)
Leptin (human), (recombinant) structure
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Common Name | Leptin (human), (recombinant) | ||
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| CAS Number | 177404-21-6 | Molecular Weight | N/A | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | N/A | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
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Leptin enhances ICAM-1 expression, induces migration and cytokine synthesis, and prolongs survival of human airway epithelial cells.
Am. J. Physiol. Lung Cell. Mol. Physiol. 309 , L801-11, (2015) There is rising interest in how obesity affects respiratory diseases, since epidemiological findings indicate a strong relationship between the two conditions. Leptin is a potent adipokine produced mainly by adipocytes. It regulates energy storage and expendi... |
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In ovo administration of human recombinant leptin shows dose dependent angiogenic effect on chicken chorioallantoic membrane.
Biol. Res. 48 , 29, (2015) Leptin, the cytokine produced by white adipose tissue is known to regulate food energy homeostasis through its hypothalamic receptor. In vitro studies have demonstrated that leptin plays a major role in angiogenesis through binding to the receptor Ob-R presen... |
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Leptin at gender-specific concentrations does not affect glucose transport, expression of glucose transporters and leptin receptors in human lymphocytes.
Endocrine 49 , 97-105, (2015) Leptin shows pleiotropic effects in organisms including an important role in the regulation of glucose homeostasis. Elevated serum leptin, particularly in obese individuals, is a warning sign of energy imbalance, hyperinsulinemia, insulin resistance and other... |
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Leptin enhances insulin sensitivity by direct and sympathetic nervous system regulation of muscle IGFBP-2 expression: evidence from nonrodent models.
Endocrinology 155(6) , 2133-43, (2014) Leptin is produced from white adipose tissue and acts primarily to regulate energy balance. Obesity is associated with leptin resistance and increased circulating levels of leptin. Leptin has recently been shown to influence levels of IGF binding protein-2 (I... |
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Critical role of large-conductance calcium- and voltage-activated potassium channels in leptin-induced neuroprotection of N-methyl-d-aspartate-exposed cortical neurons.
Pharmacol. Res. 87 , 80-6, (2014) In the present study, the neuroprotective effects of the adipokine leptin, and the molecular mechanism involved, have been studied in rat and mice cortical neurons exposed to N-methyl-d-aspartate (NMDA) in vitro. In rat cortical neurons, leptin elicited neuro... |
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Meniscus is more susceptible than cartilage to catabolic and anti-anabolic effects of adipokines.
Osteoarthr. Cartil. 23 , 1551-62, (2015) This study compared the effects on cartilage and meniscus matrix catabolism and biosynthesis of several adipokines implicated in osteoarthritis (OA).Bovine cartilage and meniscus explants were cultured for 1 or 9 days in serum-free medium alone or with 0.02, ... |
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Decreased NK cell functions in obesity can be reactivated by fat mass reduction.
Obesity (Silver Spring.) 23 , 2233-41, (2015) Natural killer (NK) cells are the first defense against malignant cells, and their functions are severely impaired in individuals with obesity. However, it is not known whether functions can be re-activated after weight loss. The alterations of NK cell functi... |
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Leptin promotes HLA-G expression on placental trophoblasts via the MEK/Erk and PI3K signaling pathways.
Placenta 36(4) , 419-26, (2015) The development of the human haemochorial placenta requires complex regulatory mechanisms to protect invasive trophoblast cells from cytotoxic responses elicited by maternal immune cells. Leptin, the adipocyte derived hormone encoded by the Lep gene, is synth... |
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A novel role of the checkpoint kinase ATR in leptin signaling.
Mol. Cell. Endocrinol. 412 , 257-64, (2015) In a world with increasing incidences of obesity, it becomes critical to understand the detailed regulation of appetite. To identify novel regulators of the signaling mediated by one of the key hormones of energy homeostasis, leptin, we screened a set of comp... |
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Leptin stimulates migration and invasion and maintains cancer stem-like properties in ovarian cancer cells: an explanation for poor outcomes in obese women.
Oncotarget 6 , 21100-19, (2015) The evidence linking obesity with ovarian cancer remains controversial. Leptin is expressed at higher levels in obese women and stimulates cell migration in other epithelial cancers. Here, we explored the clinical impact of overweight/obesity on patient progn... |