(2S)-N-[(1S)-1-(Hydroxydiphenylmethyl)-3-methylbutyl]-2-pyrrolidinecarboxamide

(2S)-N-[(1S)-1-(Hydroxydiphenylmethyl)-3-methylbutyl]-2-pyrrolidinecarboxamide Structure
(2S)-N-[(1S)-1-(Hydroxydiphenylmethyl)-3-methylbutyl]-2-pyrrolidinecarboxamide structure
Common Name (2S)-N-[(1S)-1-(Hydroxydiphenylmethyl)-3-methylbutyl]-2-pyrrolidinecarboxamide
CAS Number 910110-45-1 Molecular Weight 366.496
Density 1.1±0.1 g/cm3 Boiling Point 601.8±55.0 °C at 760 mmHg
Molecular Formula C23H30N2O2 Melting Point 193 °C
MSDS USA Flash Point 317.8±31.5 °C

Highly enantioselective direct aldol reaction catalyzed by organic molecules.

Org. Lett. 8 , 4097-4099, (2006)

We have demonstrated that a new class of l-proline-based organic compounds catalyzed the direct aldol reaction between aldehydes and acetone to provide beta-hydroxy ketones in good yields. The reaction is efficient, and 5-10 mol % of the catalyst and excellen...

Direction of Kinetically versus Thermodynamically Controlled Organocatalysis and Its Application in Chemoenzymatic Synthesis Rulli, G., et al.

Angew. Chem. Int. Ed. Engl. 50 , 1-5, (2011)