plasmin
plasmin structure
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Common Name | plasmin | ||
|---|---|---|---|---|
| CAS Number | 9001-90-5 | Molecular Weight | N/A | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C28H38N6O9S | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
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Plasmin-mediated activation of pandemic H1N1 influenza virus hemagglutinin is independent of the viral neuraminidase.
J. Virol. 87(9) , 5161-9, (2013) Influenza virus is well recognized to modulate host tropism and pathogenesis based on mutations in the proteolytic cleavage site of the viral hemagglutinin (HA), which activates HA and exposes the fusion peptide for membrane fusion. Instead of the conventiona... |
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Effects of black cohosh on the plasminogen activator system in vascular smooth muscle cells.
Maturitas 76(1) , 75-80, (2013) The rhizome of the Cimicifuga racemosa plant (commonly known as black cohosh) has been used for menopausal complaints. Studies regarding the cardiovascular effects of black cohosh are lacking. We investigated the effect of black cohosh on the plasminogen acti... |
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Functional characterization of a slow and tight-binding inhibitor of plasmin isolated from Russell's viper venom.
Biochim. Biophys. Acta 1840(1) , 153-9, (2014) Snake venoms are rich in Kunitz-type protease inhibitors that may have therapeutic applications. However, apart from trypsin or chymotrypsin inhibition, the functions of most of these inhibitors have not been elucidated. A detailed functional characterization... |
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The structure of human microplasmin in complex with textilinin-1, an aprotinin-like inhibitor from the Australian brown snake.
PLoS ONE 8(1) , e54104, (2013) Textilinin-1 is a Kunitz-type serine protease inhibitor from Australian brown snake venom. Its ability to potently and specifically inhibit human plasmin (K(i) = 0.44 nM) makes it a potential therapeutic drug as a systemic anti-bleeding agent. The crystal str... |
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A spider-derived Kunitz-type serine protease inhibitor that acts as a plasmin inhibitor and an elastase inhibitor.
PLoS ONE 8(1) , e53343, (2013) Kunitz-type serine protease inhibitors are involved in various physiological processes, such as ion channel blocking, blood coagulation, fibrinolysis, and inflammation. While spider-derived Kunitz-type proteins show activity in trypsin or chymotrypsin inhibit... |
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Surface associated antigens of Dirofilaria immitis adult worms activate the host fibrinolytic system.
Vet. Parasitol. 196(1-2) , 235-40, (2013) Cardiopulmonary dirofilariosis (Dirofilaria immitis) is characterized by apparent contradictory events, like the long-term survival of adult worms in the circulatory system of the infected hosts and the development of life-threatening events like thromboembol... |
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Characterization of three novel adhesins of Leptospira interrogans.
Am. J. Trop. Med. Hyg. 89(6) , 1103-16, (2013) We report cloning, expression, purification, and characterization of three predicted leptospiral membrane proteins (LIC11360, LIC11009, and LIC11975). In silico analysis and proteinase K accessibility data suggest that these proteins might be surface exposed.... |
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Interaction of Leptospira interrogans with human proteolytic systems enhances dissemination through endothelial cells and protease levels.
Infect. Immun. 81(5) , 1764-74, (2013) We have recently reported the ability of Leptospira to capture plasminogen (PLG) and generate plasmin (PLA) bound on the microbial surface in the presence of exogenous activators. In this work, we examined the effects of leptospiral PLG binding for active pen... |
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Microparticles: new protagonists in pericellular and intravascular proteolysis.
Semin. Thromb. Hemost. 39(1) , 33-9, (2013) Microparticles (MPs) are small vesicles resulting from the shedding of cellular membrane during activation or apoptosis processes. Beyond their well-described procoagulant property, accumulating data show that specific endothelial cell-, leukocyte-, tumor-der... |
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Requirement of plasminogen binding to its cell-surface receptor α-enolase for efficient regeneration of normal and dystrophic skeletal muscle.
PLoS ONE 7(12) , e50477, (2012) Adult regenerative myogenesis is central for restoring normal tissue structure and function after muscle damage. In muscle repair after injury, as in severe myopathies, damaged and necrotic fibers are removed by infiltrating inflammatory cells and then replac... |