Lysostaphin
Lysostaphin structure
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Common Name | Lysostaphin | ||
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| CAS Number | 9011-93-2 | Molecular Weight | 282.294 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 483.6±55.0 °C at 760 mmHg | |
| Molecular Formula | C16H14N2O3 | Melting Point | N/A | |
| MSDS | USA | Flash Point | 246.3±31.5 °C | |
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Influence of dTMP on the phenotypic appearance and intracellular persistence of Staphylococcus aureus.
Infect. Immun. 76(4) , 1333-9, (2008) Thymidine-dependent small-colony variants (SCVs) of Staphylococcus aureus are frequently associated with persistent and recurrent infections in cystic fibrosis patients. The phenotypic appearance of S. aureus SCVs or normal-colony variants (NCVs) is postulate... |
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Targeting methicillin-resistant Staphylococcus aureus with short salt-resistant synthetic peptides.
Antimicrob. Agents Chemother. 58(7) , 4113-22, (2014) The seriousness of microbial resistance combined with the lack of new antimicrobials has increased interest in the development of antimicrobial peptides (AMPs) as novel therapeutics. In this study, we evaluated the antimicrobial activities of two short synthe... |
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Leukocyte cell-derived chemotaxin 2 is a zinc-binding protein.
FEBS Lett. 587(5) , 404-9, (2013) Leukocyte cell-derived chemotaxin 2 (LECT2) is a secreted hepatic protein that has been associated with several physiological activities. LECT2 belongs to the peptidase M23 family, suggesting that it is a zinc-binding protein. To test this possibility, electr... |
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recA mediated spontaneous deletions of the icaADBC operon of clinical Staphylococcus epidermidis isolates: a new mechanism of phenotypic variations.
Antonie van Leeuwenhoek 94(2) , 317-28, (2008) Phenotypic variation of Staphylococcus epidermidis involving the slime related ica operon results in heterogeneity in surface characteristics of individual bacteria in axenic cultures. Five clinical S. epidermidis isolates demonstrated phenotypic variation, i... |
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Solution structure of the recombinant target recognition domain of zoocin A.
Proteins 81(4) , 722-7, (2013) The protein rTRD is the recombinant form of the target recognition domain of zoocin A, a lytic exoenzyme produced by Streptococcus equi subspecies zooepidemicus 4881. It has no known sequence homologs. However, the catalytic domain of zoocin A is homologous t... |
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Characterization of the staphylococcal bacteriophage lysin CHAP(K).
J. Appl. Microbiol. 111(4) , 1025-35, (2011) To develop an efficient purification strategy for the bacteriophage lysin CHAP(K) . To evaluate its antibacterial spectrum(,) enzymatic properties, optimal reaction conditions and lytic activity against live Staphlyococcus aureus.Recombinant CHAP(K) was purif... |
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MRSA decolonization of cotton rat nares by a combination treatment comprising lysostaphin and the antimicrobial peptide ranalexin.
J. Antimicrob. Chemother. 68(11) , 2569-75, (2013) To evaluate the in vivo effectiveness of a combination treatment containing ranalexin (a natural antimicrobial peptide) and lysostaphin (an antistaphylococcal endopeptidase) for reducing nasal burden of methicillin-resistant Staphylococcus aureus (MRSA).The c... |
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Bactericidal synergy of lysostaphin in combination with antimicrobial peptides.
Eur. J. Clin. Microbiol. Infect. Dis. 30(8) , 1015-21, (2011) Drug-resistant staphylococci constitute a serious problem that urgently requires the discovery of new therapeutic agents. There has been a resurgence in interest in using lysostaphin (a specific anti-staphylococcal enzyme) as a treatment for infections caused... |
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Inhibition of Staphylococcus aureus by lysostaphin-expressing Lactobacillus plantarum WCFS1 in a modified genital tract secretion medium.
Appl. Environ. Microbiol. 77(24) , 8500-8, (2011) Lactobacillus species are a predominant member of the vaginal microflora and are critical in maintaining an acidic vaginal environment thought to contribute to the prevention of a number of urogenital diseases. However, during menstruation the pH of the vagin... |
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Antibody-directed targeting of lysostaphin adsorbed onto polylactide nanoparticles increases its antimicrobial activity against S. aureus in vitro.
Nanotechnology 22(50) , 505103, (2011) The objective of this paper was to study the effect of antibody-directed targeting of S. aureus by comparing the activities of lysostaphin conjugated to biodegradable polylactide nanoparticles (NPs) in the presence and in the absence of co-immobilized anti-S.... |