Beta-Amyloid(1-40)
Beta-Amyloid(1-40) structure
|
Common Name | Beta-Amyloid(1-40) | ||
|---|---|---|---|---|
| CAS Number | 131438-79-4 | Molecular Weight | 4329.867 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C194H295N53O58S | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
|
Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides.
Science 250 , 279, (1990) The amyloid beta protein is deposited in the brains of patients with Alzheimer's disease but its pathogenic role is unknown. In culture, the amyloid beta protein was neurotrophic to undifferentiated hippocampal neurons at low concentrations and neurotoxic to ... |
|
|
Astrocytes containing amyloid beta-protein (Abeta)-positive granules are associated with Abeta40-positive diffuse plaques in the aged human brain.
Am. J. Pathol. 152 , 983-992, (1998) Amyloid beta-protein (Abeta) is the major component of senile plaques that emerge in the cortex during aging and appear most abundantly in Alzheimer's disease. In the course of our immunocytochemical study on a large number of autopsy cases, we noticed, in ma... |
|
|
Aggregation state and neurotoxic properties of Alzheimer beta-amyloid peptide.
Neurodegeneration 4 , 23-32, (1995) The behaviour of synthetic batches of beta-amyloid (beta A) 1-40 peptide in solution has been studied. The effects of beta A1-40 on a PC12 cell toxicity assay was dependent upon the time of preincubation of an aqueous solution of the peptide before applicatio... |
|
|
Evidence that the 42- and 40-amino acid forms of amyloid beta protein are generated from the beta-amyloid precursor protein by different protease activities.
Proc. Natl. Acad. Sci. U. S. A. 93 , 13170-13175, (1996) Cerebral deposition of the amyloid beta protein (A beta) is an early and invariant feature of Alzheimer disease (AD). Whereas the 40-amino acid form of A beta (A beta 40) accounts for approximately 90% of all A beta normally released from cells, it appears to... |
|
|
Trafficking of glucose, lactate, and amyloid-beta from the inferior colliculus through perivascular routes.
J. Cereb. Blood Flow Metab. 30 , 162-76, (2010) Metabolic brain imaging is widely used to evaluate brain function and disease, and quantitative assays require local retention of compounds used to register changes in cellular activity. As labeled metabolites of [1- and 6-(14)C]glucose are rapidly released i... |
|
|
Amyloid beta protein-induced neuronal cell death: neurotoxic properties of aggregated amyloid beta protein.
Brain Res. 639 , 240-244, (1994) The neurotoxic effects of soluble and aggregated synthetic amyloid beta protein (A beta P) have been investigated in rat primary cultures. Freshly solubilized beta(1-40) was neurotoxic not to immature, but to mature hippocampal neurons. On the other hand, agg... |
|
|
Amyloid beta-peptide (1-40)-mediated oxidative stress in cultured hippocampal neurons. Protein carbonyl formation, CK BB expression, and the level of Cu, Zn, and Mn SOD mRNA.
J. Mol. Neurosci. 10 , 181-192, (1998) Mechanism of amyloid beta-peptide (A beta) toxicity in cultured neurons involves the development of oxidative stress in the affected cells. A significant increase in protein carbonyl formation was detected in cultured hippocampal neurons soon after the additi... |
|
|
Differential Regulation of N-Methyl-D-Aspartate Receptor Subunits is an Early Event in the Actions of Soluble Amyloid-β(1-40) Oligomers on Hippocampal Neurons.
J. Alzheimers Dis. 51 , 197-212, (2016) Synaptic dysfunction during early stages of Alzheimer's disease (AD) is triggered by soluble amyloid-β (Aβ) oligomers that interact with NMDA receptors (NMDARs). We previously showed that Aβ induces synaptic protein loss through NMDARs, albeit through undefin... |
|
|
Aβ 1-40 enhances the proliferation of human diploid fibroblasts.
Neurobiol. Aging 38 , 11-3, (2016) There is a vast literature on the role of beta amyloid (Aβ) peptides in the pathogenesis of Alzheimer's disease. However, there is a paucity of research on the potential physiological functions of these evolutionarily conserved products of the Aβ precursor pr... |