Nutlin (3)
Nutlin (3) structure
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Common Name | Nutlin (3) | ||
|---|---|---|---|---|
| CAS Number | 548472-68-0 | Molecular Weight | 581.490 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C30H30Cl2N4O4 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
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RETRA exerts anticancer activity in Ewing's sarcoma cells independent of their TP53 status.
Eur. J. Cancer 51(7) , 841-51, (2015) Mutant p53 can exert oncogenic activity by inhibitory interaction with p73. The small-molecule RETRA has been described to disrupt this interaction and to suppress carcinoma cells (Kravchenko et al., 2008). RETRA's anticancer activity was restricted to tumour... |
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Arsenic trioxide amplifies cisplatin toxicity in human tubular cells transformed by HPV-16 E6/E7 for further therapeutic directions in renal cell carcinoma.
Cancer Lett. 356(2 Pt B) , 953-61, (2015) Human papillomavirus (HPV) DNA integrations may affect therapeutic responses in cancers through ATM network-related DNA damage response (DDR). We studied whether cisplatin-induced DDR was altered in human HK-2 renal tubular cells immortalized by HPV16 E6/E7 g... |
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Redox effects and cytotoxic profiles of MJ25 and auranofin towards malignant melanoma cells.
Oncotarget 6 , 16488-506, (2015) Malignant melanoma is the most dangerous type of skin cancer. Although recent progress in treatment has been achieved, lack of response, drug resistance and relapse remain major problems. The tumor suppressor p53 is rarely mutated in melanoma, yet it is inact... |
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Nutlin-3 loaded nanocarriers: Preparation, characterization and in vitro antineoplastic effect against primary effusion lymphoma.
Int. J. Pharm. 490 , 85-93, (2015) In this investigation, Nutlin-3 (Nut3), a novel antitumor drug with low water solubility (<0.1mg/L at 25°C), was loaded into liposomes (Lipo-Nut3), polymeric nanoparticles (NPs-Nut3) and nanoparticles engineered with an antibody direct against Syndecan-1/CD 1... |
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Host-based Prophylaxis Successfully Targets Liver Stage Malaria Parasites.
Mol. Ther. 23 , 857-65, (2015) Eliminating malaria parasites during the asymptomatic but obligate liver stages (LSs) of infection would stop disease and subsequent transmission. Unfortunately, only a single licensed drug that targets all LSs, Primaquine, is available. Targeting host protei... |
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Focal adhesion kinase and p53 synergistically decrease neuroblastoma cell survival.
J. Surg. Res. 196 , 339-49, (2015) Neuroblastoma is the most common extracranial solid tumor of childhood and is responsible for over 15% of pediatric cancer deaths. Focal adhesion kinase (FAK) is a nonreceptor tyrosine kinase that is important in many facets of neuroblastoma tumor development... |
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Toca-1 is suppressed by p53 to limit breast cancer cell invasion and tumor metastasis.
Breast Cancer Res. 16(6) , 3413, (2015) Transducer of Cdc42-dependent actin assembly-1 (Toca-1) recruits actin regulatory proteins to invadopodia, and promotes breast tumor metastasis. Since metastatic breast tumors frequently harbor mutations in the tumor suppressor p53, we tested whether p53 regu... |
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A Screen for Extracellular Signal-Regulated Kinase-Primed Glycogen Synthase Kinase 3 Substrates Identifies the p53 Inhibitor iASPP.
J. Virol. 89 , 9232-41, (2015) The Kaposi's sarcoma-associated herpesvirus (KSHV) LANA protein is essential for the replication and maintenance of virus genomes in latently KSHV-infected cells. LANA also drives dysregulated cell growth through a multiplicity of mechanisms that include alte... |
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Novel roles for p53 in the genesis and targeting of tetraploid cancer cells.
PLoS ONE 9(11) , e110844, (2014) Tetraploid (4N) cells are considered important in cancer because they can display increased tumorigenicity, resistance to conventional therapies, and are believed to be precursors to whole chromosome aneuploidy. It is therefore important to determine how tetr... |
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p53 Modulates Notch Signaling in MCF-7 Breast Cancer Cells by Associating With the Notch Transcriptional Complex Via MAML1.
J. Cell Physiol. 230 , 3115-27, (2015) p53 and Notch-1 play important roles in breast cancer biology. Notch-1 inhibits p53 activity in cervical and breast cancer cells. Conversely, p53 inhibits Notch activity in T-cells but stimulates it in human keratinocytes. Notch co-activator MAML1 binds p53 a... |