JNJ-10198409
JNJ-10198409 structure
|
Common Name | JNJ-10198409 | ||
|---|---|---|---|---|
| CAS Number | 627518-40-5 | Molecular Weight | 325.337 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 528.8±50.0 °C at 760 mmHg | |
| Molecular Formula | C18H16FN3O2 | Melting Point | N/A | |
| MSDS | USA | Flash Point | 273.6±30.1 °C | |
|
(6,7-Dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamines: platelet-derived growth factor receptor tyrosine kinase inhibitors with broad antiproliferative activity against tumor cells.
J. Med. Chem. 48 , 8163-8173, (2005) A series of (6,7-dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamines has been optimized to preserve both potent kinase inhibition activity against the angiogenesis target, the receptor tyrosine kinase of Platelet-Derived Growth Factor-BB (PDGF-BB), an... |
|
|
Validation of in vivo pharmacodynamic activity of a novel PDGF receptor tyrosine kinase inhibitor using immunohistochemistry and quantitative image analysis.
Mol. Cancer Ther. 4 , 1198-1204, (2005) With the advent of agents directed against specific molecular targets in drug discovery, it has become imperative to show a compound's cellular impact on the intended biomolecule in vivo. The objective of the present study was to determine if we could develop... |
Journals:
More...