Span 20
Span 20 structure
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Common Name | Span 20 | ||
|---|---|---|---|---|
| CAS Number | 1338-39-2 | Molecular Weight | 346.459 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 516.1±45.0 °C at 760 mmHg | |
| Molecular Formula | C18H34O6 | Melting Point | N/A | |
| MSDS | USA | Flash Point | 176.9±22.2 °C | |
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Fatty alcohols or fatty acids as niosomal hybrid carrier: effect on vesicle size, encapsulation efficiency and in vitro dye release.
Colloids Surf. B Biointerfaces 58(1) , 68-71, (2007) Niosomal hybrid mixtures are prepared with bilayer stabilizer cholesterol from non-ionic surfactants span 20 (HLB value 8.6), span 60 (HLB 4.7) and span 85 (HLB 1.8) in presence of dicetyl phosphate (DCP) where fatty acids or fatty alcohols (C14, C16 and C18)... |
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Effects of surfactant characteristics on drug availability from suppositories.
Pharmazie 63(6) , 459-63, (2008) The addition of surfactants to suppository formulations is referred to in the scientific literature, but their effects on drug availability remain uncertain. Surfactants are reported to improve drug dispersion into hard fatty excipients, to increase the sprea... |
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A novel ionic liquid-in-oil microemulsion composed of biologically acceptable components: an excitation wavelength dependent fluorescence resonance energy transfer study.
J. Phys. Chem. B 117(11) , 3221-31, (2013) In this work we have reported the formulation of a novel ionic liquid-in-oil (IL/O) microemulsion where the polar core of the ionic liquid, 1-ethyl-3-methylimidazolium n-butylsulfate ([C2mim][C4SO4]), is stabilized by a mixture of two nontoxic nonionic surfac... |
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Formulation of microemulsion systems for dermal delivery of silymarin.
AAPS PharmSciTech 13(2) , 389-99, (2012) Silymarin is a standardized extract from Silybum marianum seeds, known for its many skin benefits such as antioxidant, anti-inflammatory, and immunomodulatory properties. In this study, the potential of several microemulsion formulations for dermal delivery o... |
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Design and in vitro characterization of small unilamellar niosomes as ophthalmic carrier of dorzolamide hydrochloride.
Pharm. Dev. Technol. 19(6) , 748-54, (2014) The objective of this work was to formulate and characterize non-ionic surfactant vesicles (niosomes) as an ocular carrier of dorzolamide hydrochloride (Dorzo); one of the antiglaucoma drugs. Niosomes were prepared of Cholesterol (Chol) with sorbitan monoeste... |
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Cationic liposomes modified with non-ionic surfactants as effective non-viral carrier for gene transfer.
Colloids Surf. B Biointerfaces 49(2) , 158-64, (2006) A defined change in formulation components affects the physical and chemical characteristics of cationic liposomes (CLs) carriers in many ways. Therefore, a great degree of control can be exercised over the structure by modifying the CLs with various material... |
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Enhanced solubility and oral bioavailability of itraconazole by combining membrane emulsification and spray drying technique.
Int. J. Pharm. 434 , 264-71, (2012) The objective of the present study was to enhance solubility and bioavailability of itraconazole by a combined use of membrane emulsification and spray drying solidification technique. A shirasu-porous-glass (SPG) membrane with a mean pore size of 2.5 μm was ... |
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Development and characterization of self emulsifying drug delivery system of a poorly water soluble drug using natural oil.
Acta Pol. Pharm. 69(4) , 713-7, (2012) Objective of present study involves preparation and evaluation of self emulsifying drug delivery system (SEDDS) of ibuprofen using peanut oil. SEDDS were composed of varying concentrations of peanut oil (solvent), tween 80 (surfactant) and span 20 (co-surfact... |
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Selective accumulation of hybrid liposomes into adult T-cell leukemia cells along with induction of apoptosis.
Bioorg. Med. Chem. Lett. 21(13) , 3962-5, (2011) Markedly inhibitory effects of hybrid liposomes (HL-n) composed of 90 mol% L-α-dimyristoylphosphatidylcholine (DMPC) and 10 mol% polyoxyethylene(n) dodecyl ethers on the growth of adult T-cell leukemia cells were obtained for the first time. It is noteworthy ... |
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The effect of component of microemulsion for transdermal delivery of nicardipine hydrochloride.
Drug Dev. Ind. Pharm. 36(12) , 1398-403, (2010) Nicardipine hydrochloride has been used widely for the treatment of angina pectoris and hypertension. Because of its extensive first pass metabolism after oral administration, the transdermal administration of nicardipine microemulsions was developed in this ... |