1,3-Diphenylurea

1,3-Diphenylurea Structure
1,3-Diphenylurea structure
Common Name 1,3-Diphenylurea
CAS Number 102-07-8 Molecular Weight 212.25
Density 1.1±0.1 g/cm3 Boiling Point 374.6±25.0 °C at 760 mmHg
Molecular Formula C13H12N2O Melting Point 239-241 °C(lit.)
MSDS USA Flash Point 180.4±23.2 °C

The structure-activity relationship of urea derivatives as anti-tuberculosis agents.

Bioorg. Med. Chem. 19 , 5585-95, (2011)

The treatment of tuberculosis is becoming more difficult due to the ever increasing prevalence of drug resistance. Thus, it is imperative that novel anti-tuberculosis agents, with unique mechanisms of action, be discovered and developed. The direct anti-tuber...

Synthesis and evaluation of fluoroquinolone derivatives as substrate-based inhibitors of bacterial efflux pumps.

Eur. J. Med. Chem. 43 , 2453-63, (2008)

Bacterial efflux pump systems contribute to antimicrobial resistance in pathogenic bacteria. The co-administration of bacterial efflux pump inhibitors with antibiotics is being pursued to overcome efflux-mediated resistance to antibiotics. In this study we in...

Selectivity of kinase inhibitor fragments.

J. Med. Chem. 54 , 5131-43, (2011)

A kinase-focused screening set of fragments has been assembled and has proved successful for the discovery of ligand-efficient hits against many targets. Here we present some of our general conclusions from this exercise. Notably, we present the first profili...

Dispersive liquid-liquid microextraction for the determination of three cytokinin compounds in fruits and vegetables by liquid chromatography with time-of-flight mass spectrometry.

Talanta 116 , 376-81, (2013)

The paper presents a novel approach for the determination of three cytokinin compounds, thidiazuron (TDZ), 1,3-diphenylurea (1,3-DPU) and forchlorfenuron (CPPU), in fruit and vegetables samples using liquid chromatography with electrospray ionization and time...

Metabolism of diphenylurea by a Marinobacter sp. isolated from a contaminated ephemeral stream bed in the Negev Desert.

FEMS Microbiol. Lett. 213(2) , 199-204, (2002)

A moderate halophilic Marinobacter sp. (designated strain DPUZ) able to metabolize 1,3-diphenylurea (DPU) was isolated from a contaminated ephemeral desert stream bed near an industrial complex in the northern part of the Negev Desert (Israel). Metabolism of ...