DBCO-PEG4-Biotin
DBCO-PEG4-Biotin structure
|
Common Name | DBCO-PEG4-Biotin | ||
|---|---|---|---|---|
| CAS Number | 1255942-07-4 | Molecular Weight | 749.916 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 1062.4±65.0 °C at 760 mmHg | |
| Molecular Formula | C39H51N5O8S | Melting Point | N/A | |
| MSDS | USA | Flash Point | 596.3±34.3 °C | |
|
Rapid Cu-free click chemistry with readily synthesized biarylazacyclooctynones.
J. Am. Chem. Soc. 11th ed., 132 , 3688-3690, (2010) Bioorthogonal chemical reactions, those that do not interact or interfere with biology, have allowed for exploration of numerous biological processes that were previously difficult to study. The reaction of azides with strained alkynes, such as cyclooctynes, ... |
|
|
Copper-free click chemistry for dynamic in vivo imaging.
Proc. Natl. Acad. Sci. U. S. A. 43th ed., 104 , 16793-16797, (2007) Dynamic imaging of proteins in live cells is routinely performed by using genetically encoded reporters, an approach that cannot be extended to other classes of biomolecules such as glycans and lipids. Here, we report a Cu-free variant of click chemistry that... |
|
|
A comparative study of bioorthogonal reactions with azides.
ACS Chem. Biol. 10th ed., 1 , 644-648, (2006) Detection of metabolites and post-translational modifications can be achieved using the azide as a bioorthogonal chemical reporter. Once introduced into target biomolecules, either metabolically or through chemical modification, the azide can be tagged with p... |
|
|
Labeling, detection and identification of newly synthesized proteomes with bioorthogonal non-canonical amino-acid tagging.
Nat. Protoc. 3rd ed., 2 , 532-40, (2007) A major aim of proteomics is the identification of proteins in a given proteome at a given metabolic state. This protocol describes the step-by-step labeling, purification and detection of newly synthesized proteins in mammalian cells using the non-canonical ... |
|
|
Identification of protein targets of 4-hydroxynonenal using click chemistry for ex vivo biotinylation of azido and alkynyl derivatives.
Chem. Res. Toxicol. 2nd ed., 21 , 432-44, (2008) Polyunsaturated fatty acids (PUFA) are primary targets of free radical damage during oxidative stress. Diffusible electrophilic alpha,beta-unsaturated aldehydes, such as 4-hydroxynonenal (HNE), have been shown to modify proteins that mediate cell signaling (e... |
|
|
Robust fluorescent detection of protein fatty-acylation with chemical reporters.
J. Am. Chem. Soc. 13th ed., 131 , 4967-75, (2009) Fatty-acylation of proteins in eukaryotes is associated with many fundamental cellular processes but has been challenging to study due to limited tools for rapid and robust detection of protein fatty-acylation in cells. The development of azido-fatty acids en... |
|
|
Ning, X., et al.
Angew. Chem. Int. Ed. Engl. 47 , 2253-5
|