Epidermal Growth Factor
Epidermal Growth Factor structure
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Common Name | Epidermal Growth Factor | ||
|---|---|---|---|---|
| CAS Number | 62253-63-8 | Molecular Weight | 6221.96723999994 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C270H401N73O83S7 | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
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Neuropilin 1 is an entry factor that promotes EBV infection of nasopharyngeal epithelial cells.
Nat. Commun. 6 , 6240, (2015) Epstein-Barr virus (EBV) is implicated as an aetiological factor in B lymphomas and nasopharyngeal carcinoma. The mechanisms of cell-free EBV infection of nasopharyngeal epithelial cells remain elusive. EBV glycoprotein B (gB) is the critical fusion protein f... |
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Neurobehavioral Differences Between Mice Receiving Distinct Neuregulin Variants as Neonates; Impact on Sensitivity to MK-801.
Curr. Mol. Med. 15 , 222-36, (2015) Neuregulin-1 (NRG1) is a well-recognized risk gene for schizophrenia and is often implicated in the neurodevelopmental hypothesis of this illness. Alternative splicing and proteolytic processing of the NRG1 gene produce more than 30 structural variants; howev... |
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Inhibition of non-small cell lung cancer (NSCLC) growth by a novel small molecular inhibitor of EGFR.
Oncotarget 6(9) , 6749-61, (2015) The epidermal growth factor receptor (EGFR) is a therapeutic target (oncotarget) in NSCLC. Using in vitro EGFR kinase activity system, we identified a novel small molecule, WB-308, as an inhibitor of EGFR. WB-308 decreased NSCLC cell proliferation and colony ... |
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EGFR and HER2 signals play a salvage role in MEK1-mutated gastric cancer after MEK inhibition.
Int. J. Oncol. 47 , 499-505, (2015) Since the prognosis of unresectable advanced gastric cancer remains poor, novel therapeutic strategies are needed. Somatic MEK1 gene mutations have been reported as oncogenic activating mutations in gastric cancer, and MEK inhibitors can be effective against ... |
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Development of polyether urethane intravaginal rings for the sustained delivery of hydroxychloroquine.
Drug Des. Devel. Ther. 8 , 1801-15, (2014) Hydroxychloroquine (HCQ) has been shown to demonstrate anti-inflammatory properties and direct anti-HIV activity. In this study, we describe for the first time the fabrication and in vitro evaluation of two types of intravaginal ring (IVR) devices (a surfaced... |
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FoxO1-negative cells are cancer stem-like cells in pancreatic ductal adenocarcinoma.
Sci. Rep. 5 , 10081, (2015) Flow cytometry assays using aldehyde dehydrogenase (ALDH) activity or CD133 positivity to isolate cancer stem cells (CSCs) are widely applied but have limitations. Thus, characterization of CSC makers for a specific cancer is potentially important. We have pr... |
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PLGA/gelatin hybrid nanofibrous scaffolds encapsulating EGF for skin regeneration.
J. Biomed. Mater. Res. A 103 , 2225-35, (2015) The novel strategies of skin regenerative treatment are aimed at the development of biologically responsive scaffolds capable of delivering multiple bioactive agents and cells to the target tissues. In this study, nanofibers of poly(lactic-co-glycolic acid) (... |
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Key role of dual specificity kinase TTK in proliferation and survival of pancreatic cancer cells.
Br. J. Cancer 111(9) , 1780-7, (2014) Pancreatic ductal adenocarcinoma (PDAC) is among the most aggressive human malignancies with an overall 5-year survival rate of <5%. Despite significant advances in treatment of the disease during the past decade, the median survival rate (∼6 months) has hard... |
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Sustained Inhibition of Proliferative Response After Transient FGF Stimulation Is Mediated by Interleukin 1 Signaling.
J. Cell Physiol. 231 , 650-8, (2015) Transient FGF stimulation of various cell types results in FGF memory--a sustained blockage of efficient proliferative response to FGF and other growth factors. FGF memory establishment requires HDAC activity, indicating its epigenetic character. FGF treatmen... |
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White matter tracts for the trafficking of neural progenitor cells characterized by cellular MRI and immunohistology: the role of CXCL12/CXCR4 signaling.
Brain Struct. Funct. , (2014) White matter tracts are important for the trafficking of neural progenitor cells (NPCs) in both normal and pathological conditions, but the underlying mechanism is not clear. The directionality of white matter is advantageous for molecules or cells to distrib... |