(Nle8·18,Tyr34)-pTH (1-34) amide (bovine)
(Nle8·18,Tyr34)-pTH (1-34) amide (bovine) structure
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Common Name | (Nle8·18,Tyr34)-pTH (1-34) amide (bovine) | ||
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| CAS Number | 64763-77-5 | Molecular Weight | 4087.65 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C185H293N55O50 | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
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Parathyroid hormone stimulation of mitosis in rat thymic lymphocytes is independent of cyclic AMP.
J. Bone Miner Res. 2(4) , 303-9, (1987) The in vitro mitotic response of rat thymic lymphocytes to hPTH(1-34), hPTH (1-38), and 8,18 Nle hPTH(1-34) exhibits a dependency upon extracellular calcium. Removal of extracellular calcium or the addition of Verapamil (5 micrograms/ml) or trifluoroperazine ... |
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Parathyroid hormone receptors in circulating human mononuclear leukocytes.
J. Biol. Chem. 259(9) , 5531-5, (1984) In this article we demonstrate receptors for parathyroid hormone in circulating mononuclear leukocytes using the radioiodinated analogue (8,18 norleucine, 34 tyrosine) bPTH 1-34 (bovine parathyroid hormone 1-34). Specific binding, which is reversible and satu... |
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Treatment of bone-derived ROS 17/2.8 cells with dexamethasone and pertussis toxin enables detection of partial agonist activity for parathyroid hormone antagonists.
Endocrinology 127(1) , 76-82, (1990) In the design and biological evaluation of PTH antagonists, certain analogs, although antagonists in vitro, possess partial agonist properties in vivo that preclude their utility as antagonists. In an effort to identify weak agonism of PTH analogs, an attempt... |
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Binding and degradation of NH2-terminal parathyroid hormone by opossum kidney cells.
Am. J. Physiol. 260(4 Pt 1) , E544-52, (1991) The binding and cellular processing of NH2-terminal parathyroid (PTH) hormone by confluent monolayers of opossum kidney (OK) cells was characterized using radiolabeled PTH peptide analogues. Time- and temperature-dependent specific binding of 125I-labeled (Nl... |
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Biologic activity of 8,18-norleucine 34-tyrosine parathyroid hormone (1-34) amide in chicken kidney and bone.
Comp. Biochem. Physiol. A. Comp. Physiol. 73(4) , 691-5, (1982)
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The structure of parathyroid hormone: its effects on biological action.
Miner. Electrolyte Metab. 8(3-4) , 159-72, (1982)
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Functional properties of parathyroid hormone receptors.
Miner. Electrolyte Metab. 8(3-4) , 151-8, (1982)
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Site-specific biotinylation. A novel approach and its application to endothelin-1 analogs and PTH-analog.
Int. J. Pept. Protein Res. 40(6) , 567-74, (1992) We have developed an expeditious method for the incorporation of the biotinylaminocaproyl moiety on the epsilon-amino group of a lysine residue within a peptide chain in a site-specific manner. Using t-Boc chemistry for the solid phase synthesis approach and ... |
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Parathyroid hormone stimulates adenylate cyclase in rat cerebral microvessels.
Life Sci. 32 , 1009-1014, (1983) We have studied the effect of parathyroid hormone (PTH) on adenylate cyclase of microvessels isolated from rat cerebral cortex. Native bovine (b) PTH-(1-84), the synthetic amino-terminal fragment bPTH-(1-34) and the synthetic analog [Nle8,Nle18,Tyr34]-bPTH- (... |
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Structure-activity relationship of parathyroid hormone: relative sensitivity of rabbit renal microvessel and tubule adenylate cyclases to oxidized PTH and PTH inhibitors.
Eur. J. Pharmacol. 140 , 247-257, (1987) It has been shown previously that secondary structural changes of bPTH-(1-34) (synthetic amino-terminal (1-34) fragment of bovine parathyroid hormone), obtained by oxidation of the methionines 8 and 18, abolished its hypotensive but not its hypercalcemic acti... |