Glyoxalase I, from Saccharomyces cerevisiae
Glyoxalase I, from Saccharomyces cerevisiae structure
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Common Name | Glyoxalase I, from Saccharomyces cerevisiae | ||
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| CAS Number | 9033-12-9 | Molecular Weight | N/A | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | N/A | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
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Grape powder supplementation prevents oxidative stress-induced anxiety-like behavior, memory impairment, and high blood pressure in rats.
J. Nutr. 143(6) , 835-42, (2013) We examined whether or not grape powder treatment ameliorates oxidative stress-induced anxiety-like behavior, memory impairment, and hypertension in rats. Oxidative stress in Sprague-Dawley rats was produced by using L-buthionine-(S,R)-sulfoximine (BSO). Four... |
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Macrophage activation and differentiation signals regulate schlafen-4 gene expression: evidence for Schlafen-4 as a modulator of myelopoiesis.
PLoS ONE 6(1) , e15723, (2011) The ten mouse and six human members of the Schlafen (Slfn) gene family all contain an AAA domain. Little is known of their function, but previous studies suggest roles in immune cell development. In this report, we assessed Slfn regulation and function in mac... |
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Exogenous sodium nitroprusside alleviates arsenic-induced oxidative stress in wheat (Triticum aestivum L.) seedlings by enhancing antioxidant defense and glyoxalase system.
Ecotoxicology 22(3) , 584-96, (2013) The present study investigates the possible regulatory role of exogenous nitric oxide (NO) in mitigating oxidative stress in wheat seedlings exposed to arsenic (As). Seedlings were treated with NO donor (0.25 mM sodium nitroprusside, SNP) and As (0.25 and 0.5... |
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Advanced glycation endproducts and its receptor for advanced glycation endproducts in obesity.
Curr. Opin. Lipidol. 24(1) , 4-11, (2013) To highlight the potential importance of advanced glycation endproducts (AGEs) and advanced-lipoxidation endproducts (ALEs) in obesity and obesity-related complications, and the contribution of the receptor for advanced glycation endproducts (RAGE) and the gl... |
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A novel mechanism of methylglyoxal cytotoxicity in prostate cancer cells.
Int. J. Biochem. Cell Biol. 45(4) , 836-44, (2013) Methylglyoxal is one of the most powerful glycating agents of proteins and other important cellular components and has been shown to be toxic to cultured cells. Methylglyoxal cytotoxicity appears to occur through cell-cycle arrest but, more often, through ind... |
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The glyoxalase pathway: the first hundred years... and beyond.
Biochem. J. 453(1) , 1-15, (2013) The discovery of the enzymatic formation of lactic acid from methylglyoxal dates back to 1913 and was believed to be associated with one enzyme termed ketonaldehydemutase or glyoxalase, the latter designation prevailed. However, in 1951 it was shown that two ... |
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Glyoxalase 1 and its substrate methylglyoxal are novel regulators of seizure susceptibility.
Epilepsia 54(4) , 649-57, (2013) Epilepsy is a complex disease characterized by a predisposition toward seizures. There are numerous barriers to the successful treatment of epilepsy. For instance, current antiepileptic drugs have adverse side effects and variable efficacies. Furthermore, the... |
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'Chiral compartmentation' in metabolism: enzyme stereo-specificity yielding evolutionary options.
FEBS Lett. 587(17) , 2790-7, (2013) We introduce the concept of 'chiral compartmentation' in metabolism that emerges from the stereo-specificity of enzymes for their substrate(s). The fully differentiated mammalian erythrocyte has no sub-cellular organelles and yet it displays compartmentation ... |
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Acute glutathione depletion induces hepatic methylglyoxal accumulation by impairing its detoxification to D-lactate.
Exp. Biol. Med. (Maywood.) 238(4) , 360-9, (2013) Methylglyoxal (MGO) is a dicarbonyl that reacts with amino acids and nucleic acids to form advanced glycation endproducts, which may contribute to diabetes and its cardiovascular complications. MGO detoxification through the glyoxalase (GLO) pathway is glutat... |
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Methylglyoxal alters glucose metabolism and increases AGEs content in C6 glioma cells.
Metab. Brain Dis. 27(4) , 531-9, (2012) Methylglyoxal is a dicarbonyl compound that is physiologically produced by enzymatic and non-enzymatic reactions. It can lead to cytotoxicity, which is mainly related to Advanced Glycation End Products (AGEs) formation. Methylglyoxal and AGEs are involved in ... |