Deoxyribonuclease II
Deoxyribonuclease II structure
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Common Name | Deoxyribonuclease II | ||
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| CAS Number | 9025-64-3 | Molecular Weight | N/A | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | N/A | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
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Identification of neutral and acidic deoxyribonuclease activities in Tetrahymena thermophila life stages.
Eur. J. Protistol. 51 , 173-85, (2015) Deoxyribonucleases (DNases) play a major role in apoptotic DNA fragmentation/degradation, and apoptotic-like DNA degradation is also observed during conjugation of the ciliate Tetrahymena thermophila; however, the characteristics of neutral and acidic DNases ... |
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The story of DNase II: a stifled death-wish leads to self-harm.
Eur. J. Immunol. 40(9) , 2376-8, (2010) DNase II is an endonuclease which plays a fundamental role in the degradation of DNA from both apoptotic cells, and nuclei extruded from red blood cells during erythropoiesis: important tasks, considering that everyday 10(8)-10(9) cells undergo apoptosis, and... |
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DNase 2 is the main DNA-degrading enzyme of the stratum corneum.
PLoS ONE 6(3) , e17581, (2011) The cornified layer, the stratum corneum, of the epidermis is an efficient barrier to the passage of genetic material, i.e. nucleic acids. It contains enzymes that degrade RNA and DNA which originate from either the living part of the epidermis or from infect... |
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Klf1 affects DNase II-alpha expression in the central macrophage of a fetal liver erythroblastic island: a non-cell-autonomous role in definitive erythropoiesis.
Mol. Cell. Biol. 31(19) , 4144-54, (2011) A key regulatory gene in definitive erythropoiesis is the erythroid Kruppel-like factor (Eklf or Klf1). Klf1 knockout (KO) mice die in utero due to severe anemia, while residual circulating red blood cells retain their nuclei. Dnase2a is another critical gene... |
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Horizontal gene transfer: You are what you eat
Biochem. Biophys. Res. Commun. 396(1) , 147-51, (2010) Horizontal or lateral gene transfer is an effective mechanism for the exchange of genetic information in bacteria allowing bacterial diversification and facilitating adaptation to new environments. Recent data demonstrate that DNA may also be transferred betw... |
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5'-Phosphate oligodeoxynucleotides enhance the phosphodiester-CpG DNA-induced inflammatory response in macrophages.
Eur. J. Immunol. 41(2) , 425-36, (2011) Dying cells release genomic DNA into the surroundings where the DNA is first degraded to oligodeoxynucleotides, then to nucleotides, nucleosides and so on. Given that the unmethylated CpG dinucleotide (CpG motif), which is characteristic of bacterial DNA, is ... |
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Oxidant stress in mitochondrial DNA damage, autophagy and inflammation in atherosclerosis.
Sci. Rep. 3 , 1077, (2013) Our studies in HUVECs show that ox-LDL induced autophagy and damaged mtDNA leading to TLR9 expression. LOX-1 antibody or the ROS inhibitor apocynin attenuated ox-LDL-mediated autophagy, mtDNA damage and TLR9 expression, suggesting that these events are LOX-1 ... |
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NMR structure and function of Helicoverpa armigera sterol carrier protein-2, an important insecticidal target from the cotton bollworm.
Acta Biomater. 7(4) , 1580-7, (2011) The cotton bollworm, Helicoverpa armigera, has developed strong resistance to many insecticides. Sterol Carrier Protein-2 (SCP-2) is an important non-specific lipid transfer protein in insects and appears to be a potential new target. In order to elucidate th... |
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Genetic and expression analysis of SNPs in the human deoxyribonuclease II: SNPs in the promoter region reduce its in vivo activity through decreased promoter activity.
Electrophoresis 33(18) , 2852-8, (2012) Five SNPs in the human DNase II gene have been reported to be associated with rheumatoid arthritis (RA). Genotype and haplotype analysis of 14 SNPs, nine SNPs of which reported in the NCBI dbSNP database in addition to these five SNPs, was performed in health... |
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Coordinated and sequential activation of neutral and acidic DNases during interdigital cell death in the embryonic limb.
Apoptosis 15(10) , 1197-210, (2010) Interdigital tissue regression during embryonic development is one of the most representative model systems of morphogenetic cell death, but the degenerative cascade accounting for this process awaits clarification. Although the canonical apoptotic caspase pa... |