Cathepsin C, from bovine spleen
Cathepsin C, from bovine spleen structure
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Common Name | Cathepsin C, from bovine spleen | ||
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| CAS Number | 9032-68-2 | Molecular Weight | N/A | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | N/A | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
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Cathepsin C is a tissue-specific regulator of squamous carcinogenesis.
Genes Dev. 27(19) , 2086-98, (2013) Serine and cysteine cathepsin (Cts) proteases are an important class of intracellular and pericellular enzymes mediating multiple aspects of tumor development. Emblematic of these is CtsB, reported to play functionally significant roles during pancreatic isle... |
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Cathepsin C and plasma glutamate carboxypeptidase secreted from Fischer rat thyroid cells liberate thyroxin from the N-terminus of thyroglobulin.
Biochimie 94(3) , 719-26, (2012) The release of a thyroid hormone from thyroglobulin is controlled by a complex regulatory system. We focused on the extracellular action of two lysosomal enzymes, cathepsin C (catC, dipeptidyl peptidase I) and PGCP (lysosomal dipeptidase), on thyroglobulin, a... |
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The IL-1-dependent sterile inflammatory response has a substantial caspase-1-independent component that requires cathepsin C.
J. Immunol. 189(7) , 3734-40, (2012) The sterile inflammatory response to cell death and irritant crystals is medically important because it causes disease. Although these stimuli are structurally distinct, they cause inflammation through a common pathway that requires the cytokine IL-1. In vitr... |
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Cathepsin-mediated necrosis controls the adaptive immune response by Th2 (T helper type 2)-associated adjuvants.
J. Biol. Chem. 288(11) , 7481-91, (2013) Immunologic adjuvants are critical components of vaccines, but it remains unclear how prototypical adjuvants enhance the adaptive immune response. Recent studies have shown that necrotic cells could trigger an immune response. Although most adjuvants have bee... |
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Mice deficient in LMAN1 exhibit FV and FVIII deficiencies and liver accumulation of α1-antitrypsin.
Blood 118(12) , 3384-91, (2011) The type 1-transmembrane protein LMAN1 (ERGIC-53) forms a complex with the soluble protein MCFD2 and cycles between the endoplasmic reticulum (ER) and the ER-Golgi intermediate compartment (ERGIC). Mutations in either LMAN1 or MCFD2 cause the combined deficie... |
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Cathepsin C inhibitors: property optimization and identification of a clinical candidate.
J. Med. Chem. 57(6) , 2357-67, (2014) A lead generation and optimization program delivered the highly selective and potent CatC inhibitor 10 as an in vivo tool compound and potential development candidate. Structural studies were undertaken to generate SAR understanding. |
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Olfactomedin 4 inhibits cathepsin C-mediated protease activities, thereby modulating neutrophil killing of Staphylococcus aureus and Escherichia coli in mice.
J. Immunol. 189(5) , 2460-7, (2012) Neutrophils kill bacteria generally through oxidative and nonoxidative mechanisms. Whereas much research has focused on the enzymes essential for neutrophil killing, little is known about the regulatory molecules responsible for such killing. In this study, w... |
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Olfm4 deletion enhances defense against Staphylococcus aureus in chronic granulomatous disease.
J. Clin. Invest. 123(9) , 3751-5, (2013) Chronic granulomatous disease (CGD) patients have recurrent life-threatening bacterial and fungal infections. Olfactomedin 4 (OLFM4) is a neutrophil granule protein that negatively regulates host defense against bacterial infection. The goal of this study was... |
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Up-regulation of microglial cathepsin C expression and activity in lipopolysaccharide-induced neuroinflammation.
J. Neuroinflammation 9 , 96, (2012) Cathepsin C (Cat C) functions as a central coordinator for activation of many serine proteases in inflammatory cells. It has been recognized that Cat C is responsible for neutrophil recruitment and production of chemokines and cytokines in many inflammatory d... |
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Lysosome-membrane fusion mediated superoxide production in hyperglycaemia-induced endothelial dysfunction.
PLoS ONE 7(1) , e30387, (2012) Lysosomal exocytosis and fusion to cellular membrane is critical in the oxidative stress formation of endothelium under apoptotic stimulus. We investigated the role therein of it in hyperglycaemia-induced endothelial dysfunction. The lysosome-membrane fusion ... |