Cathepsin L
Cathepsin L structure
|
Common Name | Cathepsin L | ||
|---|---|---|---|---|
| CAS Number | 60616-82-2 | Molecular Weight | N/A | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | N/A | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
|
A novel photoaffinity-based probe for selective detection of cathepsin L active form.
ChemBioChem. 13(17) , 2616-21, (2012) Detecting the active forms of proteases by using activity-based probes in complex proteomes has become an intensively investigated field of research over the past years because many pathogenic conditions involve alterations in protease activities. The detecti... |
|
|
Elastin degradation by cathepsin V requires two exosites.
J. Biol. Chem. 288(48) , 34871-81, (2013) Cathepsin V is a highly effective elastase and has been implicated in physiological and pathological extracellular matrix degradation. However, its mechanism of action remains elusive. Whereas human cathepsin V exhibits a potent elastolytic activity, the stru... |
|
|
Acetate-induced apoptosis in colorectal carcinoma cells involves lysosomal membrane permeabilization and cathepsin D release.
Cell Death Dis. 4 , e507, (2013) Colorectal carcinoma (CRC) is one of the most common causes of cancer-related mortality. Short-chain fatty acids secreted by dietary propionibacteria from the intestine, such as acetate, induce apoptosis in CRC cells and may therefore be relevant in CRC preve... |
|
|
Pharmacological activation of the pyruvate dehydrogenase complex reduces statin-mediated upregulation of FOXO gene targets and protects against statin myopathy in rodents.
J. Physiol. 590(Pt 24) , 6389-402, (2012) We previously reported that statin myopathy is associated with impaired carbohydrate (CHO) oxidation in fast-twitch rodent skeletal muscle, which we hypothesised occurred as a result of forkhead box protein O1 (FOXO1) mediated upregulation of pyruvate dehydro... |
|
|
Three-dimensional cultures modeling premalignant progression of human breast epithelial cells: role of cysteine cathepsins.
Biol. Chem. 393(12) , 1405-16, (2012) The expression of the cysteine protease cathepsin B is increased in early stages of human breast cancer.To assess the potential role of cathepsin B in premalignant progression of breast epithelial cells, we employed a 3D reconstituted basement membrane overla... |
|
|
Proteolysis and cathepsin activities in the processing of dry-cured duck.
Poult. Sci. 93(3) , 687-94, (2014) Changes in sarcoplasmic and myofibrillar proteins, free amino acids, and cathepsin activities were measured to evaluate the contribution of cathepsins to the proteolysis of muscle proteins in dry-cured duck processing. Thirty-six dry-cured ducks were processe... |
|
|
Identification of pathogenic T cell epitopes near cathepsin cleavage sites in thyroglobulin.
J. Immunol. 190(4) , 1466-71, (2013) Experimental autoimmune thyroiditis, induced in mice after challenge with thyroglobulin (Tg), is known to be under the genetic control of the H2A(k) locus. Because cathepsins are known to influence proteolytic processing of Tg in vivo, we examined in this stu... |
|
|
Non-canonical maturation of two papain-family proteases in Toxoplasma gondii.
J. Biol. Chem. 288(5) , 3523-34, (2013) Proteases regulate key events during infection by the pervasive intracellular parasite Toxoplasma gondii. Understanding how parasite proteases mature from an inactive zymogen to an active enzyme is expected to inform new strategies for blocking their actions.... |
|
|
Active center differences between cathepsins L and B: the S1 binding region.
FEBS Lett. 228(1) , 128-30, (1988) The substrate peptide bond cleaved by cathepsins B and L is determined not by the amino acid contributing the carboxyl group to this bond as in the case of serine proteases but rather by the presence of a neighboring amino acid with a large hydrophobic side c... |
|
|
Autophagic-lysosomal pathway is the main proteolytic system modified in the skeletal muscle of esophageal cancer patients.
Am. J. Clin. Nutr. 98(6) , 1485-92, (2013) In cancer cachexia, muscle depletion is related to morbidity and mortality. Muscle-wasting mechanisms in cancer patients are not fully understood.We investigated the involvement of the proteolytic systems (proteasome, autophagic-lysosomal, calpain, and caspas... |