chondroitinase abc
chondroitinase abc structure
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Common Name | chondroitinase abc | ||
|---|---|---|---|---|
| CAS Number | 9024-13-9 | Molecular Weight | 130.077 | |
| Density | 1.7±0.1 g/cm3 | Boiling Point | 401.4±48.0 °C at 760 mmHg | |
| Molecular Formula | C4H3FN2O2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 196.5±29.6 °C | |
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Perineuronal net degradation in epilepsy.
Epilepsia 56 , 1124-33, (2015) We previously reported loss of perineuronal net (PN) immunohistochemical staining around parvalbumin-positive interneurons in the hippocampus of rats after an episode of status epilepticus (SE). We hypothesized that the loss of the PN could alter seizure susc... |
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Abnormalities in Expression of Structural, Barrier and Differentiation Related Proteins, and Chondroitin Sulfate in Feline and Human Interstitial Cystitis.
J. Urol. 194 , 571-7, (2015) We analyzed the urothelium of cats diagnosed with feline interstitial cystitis to determine whether abnormalities in protein expression patterns could be detected and whether the expression pattern was similar to that in patients with human interstitial cysti... |
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Focal experimental injury leads to widespread gene expression and histologic changes in equine flexor tendons.
PLoS ONE 10(4) , e0122220, (2015) It is not known how extensively a localised flexor tendon injury affects the entire tendon. This study examined the extent of and relationship between histopathologic and gene expression changes in equine superficial digital flexor tendon after a surgical inj... |
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Enhanced in vitro chondrogenesis of primary mesenchymal stem cells by combined gene transfer.
Tissue Eng. Part A 15(5) , 1127-39, (2009) Because articular cartilage has a poor regeneration capacity, numerous cell-based approaches to therapy are currently being explored. The present study involved the use of gene transfer as a means to provide sustained delivery of chondrogenic proteins to prim... |
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Extracellular-matrix-based and Arg-Gly-Asp-modified photopolymerizing hydrogels for cartilage tissue engineering.
Tissue Eng. Part A 21(3-4) , 757-66, (2015) Articular cartilage damage is a persistent and increasing problem with the aging population. Strategies to achieve complete repair or functional restoration remain a challenge. Photopolymerizing-based hydrogels have long received an attention in the cartilage... |
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Loss of corneal epithelial heparan sulfate leads to corneal degeneration and impaired wound healing.
Invest. Ophthalmol. Vis. Sci. 56 , 3004-14, (2015) Heparan sulfate (HS) is a highly modified glycosaminoglycan (GAG) bound to a core protein to form heparan sulfate proteoglycans (HSPGs) that are vital in many cellular processes ranging from development to adult physiology, as well as in disease, through inte... |
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Loss of Endocan tumorigenic properties after alternative splicing of exon 2.
BMC Cancer 8 , 14, (2008) Endocan was originally described as a dermatan sulfate proteoglycan found freely circulating in the blood. Endocan expression confers tumorigenic properties to epithelial cell lines or accelerate the growth of already tumorigenic cells. This molecule is the p... |
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Chondroitin Sulfate Induces Depression of Synaptic Transmission and Modulation of Neuronal Plasticity in Rat Hippocampal Slices.
Neural Plast. 2015 , 463854, (2015) It is currently known that in CNS the extracellular matrix is involved in synaptic stabilization and limitation of synaptic plasticity. However, it has been reported that the treatment with chondroitinase following injury allows the formation of new synapses ... |
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Glypican-5 stimulates rhabdomyosarcoma cell proliferation by activating Hedgehog signaling.
J. Cell Biol. 192 , 691-704, (2011) Glypican-5 (GPC5) is one of the six members of the glypican family. It has been previously reported that GPC5 stimulates the proliferation of rhabdomyosarcoma cells. In this study, we show that this stimulatory activity of GPC5 is a result of its ability to p... |
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T-type calcium channels contribute to calcium disturbances in brain during hyponatremia.
Exp. Neurol. 273 , 105-13, (2015) Disturbance of calcium homeostasis is implicated in the normal process of aging and brain pathology prevalent in the elderly such as Alzheimer's, Parkinson's, and amyotrophic lateral sclerosis. Previous studies demonstrated that applying a hyponatremic iso-os... |