Chondroitinase AC
Chondroitinase AC structure
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Common Name | Chondroitinase AC | ||
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| CAS Number | 9047-57-8 | Molecular Weight | N/A | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | N/A | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
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Crystallization and preliminary analysis of chondroitinase AC from Flavobacterium heparinum.
Acta Crystallogr. D Biol. Crystallogr. 54(Pt 2) , 279-280, (1998) Chondroitinase AC (E.C. 4.2.2.5) overexpressed in its host, Flavobacterium heparinum, was crystallized by vapor diffusion using polyethylene glycol methyl ether as precipitant. It crystallizes in the space group P43212 or its enantiomorph with a = b = 87.1 an... |
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Anti-tumor activities of chondroitinase AC and chondroitinase B: inhibition of angiogenesis, proliferation and invasion.
Eur. J. Pharmacol. 416 , 213-221, (2001) In the current study, two specific glycosaminoglycan lyases, chondroitinase AC and chondroitinase B, were utilized to examine the roles of chondroitin sulfates and dermatan sulfate in tumor metastasis and angiogenesis. Melanoma cells (SK-MEL) or endothelial c... |
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An improved methodology to produce Flavobacterium heparinum chondroitinases, important instruments for diagnosis of diseases.
Biotechnol. Appl. Biochem. 37(2) , 115-127, (2003) Chondroitinases are very important tools for the identification and structural analysis of proteoglycans. Enzymic analysis with Flavobacterium heparinum chondroitinases has shown that chondroitin sulphate and dermatan sulphate structures are modified in many ... |
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Purification and properties of bacterial chondroitinases and chondrosulfatases.
J. Biol. Chem. 243 , 1523, (1968)
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Studies on the enzyme chondroitinase: product structure and ion effects.
Arch. Biochem. Biophys. 94 , 244-251, (1961)
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Recombinant expression, purification, and kinetic characterization of chondroitinase AC and chondroitinase B from Flavobacterium heparinum.
Biochem. Biophys. Res. Commun. 286(2) , 343-351, (2001) Glycosaminoglycans (GAGs) are a family of complex polysaccharides involved in a diversity of biological processes, ranging from cell signaling to blood coagulation. Chondroitin sulfate (CS) and dermatan sulfate (DS) comprise a biologically important subset of... |
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Characterization of oligosaccharides from the chondroitin/dermatan sulfates. 1H-NMR and 13C-NMR studies of reduced trisaccharides and hexasaccharides.
FEBS J. 272(24) , 6276-86, (2005) Chondroitin and dermatan sulfate (CS and DS) chains were isolated from bovine tracheal cartilage and pig intestinal mucosal preparations and fragmented by enzymatic methods. The oligosaccharides studied include a disaccharide and hexasaccharides from chondroi... |
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Structural and sequence motifs in dermatan sulfate for promoting fibroblast growth factor-2 (FGF-2) and FGF-7 activity.
J. Biol. Chem. 280(7) , 5300-6, (2005) Glycosaminoglycans have been implicated in the binding and activation of a variety of growth factors, cytokines, and chemokines. In this way, glycosaminoglycans are thought to participate in events such as development and wound repair. In particular, heparin ... |
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Structural characterization and antithrombin activity of dermatan sulfate purified from marine clam Scapharca inaequivalvis.
Glycobiology 19(4) , 356-67, (2009) Glycosaminoglycans from the body of marine clam Scapharca inaequivalvis were extracted at about 0.15- 0.18 mg/g of dry tissue, composed of dermatan sulfate (DS) (approx. 74%) and heparan sulfate (26%). After treatment with nitrous acid, DS was isolated for fu... |
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Determination of chondroitin sulfate content in raw materials and dietary supplements by high-performance liquid chromatography with ultraviolet detection after enzymatic hydrolysis: single-laboratory validation.
J. AOAC Int. 90 , 659-669, (2007) A method to quantify chondroitin sulfate in raw materials and dietary supplements at a range of about 5 to 100% (w/w) chondroitin sulfate has been developed and validated. The chondroitin sulfate is first selectively hydrolyzed by chondroitinase ACII enzyme t... |