TRAP-6

TRAP-6 Structure
TRAP-6 structure
Common Name TRAP-6
CAS Number 141136-83-6 Molecular Weight 748.87000
Density N/A Boiling Point N/A
Molecular Formula C34H56N10O9 Melting Point N/A
MSDS Chinese USA Flash Point N/A

Clinical effects of phosphodiesterase 3A mutations in inherited hypertension with brachydactyly.

Hypertension 66 , 800-8, (2015)

Autosomal-dominant hypertension with brachydactyly is a salt-independent Mendelian syndrome caused by activating mutations in the gene encoding phosphodiesterase 3A. These mutations increase the protein kinase A-mediated phosphorylation of phosphodiesterase 3...

Impact of variables of the P-selectin - P-selectin glycoprotein ligand-1 axis on leukocyte-platelet interactions in cardiovascular disease.

Thromb. Haemost. 113(4) , 806-12, (2015)

The formation of leukocyte-platelet aggregates (LPA), through the P-selectin - P-selectin glycoprotein ligand (PSGL)-1 axis, plays a pivotal role in atherothrombosis. In order to investigate the influence of platelet (pP-selectin) and soluble P-selectin (sP-s...

Activated platelets present high mobility group box 1 to neutrophils, inducing autophagy and promoting the extrusion of neutrophil extracellular traps.

J. Thromb. Haemost. 12(12) , 2074-88, (2014)

Increasing evidence implicates both platelets and neutrophils in the formation, stabilization, and growth of peripheral and coronary thrombi. Neutrophil extracellular traps (NETs) play a key role. The early events in the deregulated cross-talk between platele...

Sex differences of leukocyte-platelet interactions and on-treatment platelet reactivity in patients with atherosclerosis.

Atherosclerosis 237(2) , 692-5, (2014)

To investigate differences of platelet activation and on-treatment residual platelet reactivity between female and male patients with atherosclerotic cardiovascular disease.We compared P-selectin expression, activated glycoprotein (GP) IIb/IIIa and leukocyte-...

Pro-thrombotic effect of exercise in a polluted environment: a P-selectin- and CD63-related platelet activation effect.

Thromb. Haemost. 113(1) , 118-24, (2015)

Exposure to diesel exhaust is an important cardiovascular risk factor and may promote atherothrombotic events. Some data suggest that polluted air exposure could affect haemostasis through platelet activation. The aim of the study was to investigate the effec...

Thrombin-dependent NF-{kappa}B activation and monocyte/endothelial adhesion are mediated by the CARMA3·Bcl10·MALT1 signalosome.

J. Thorac. Cardiovasc. Surg. 285 , 41432-42, (2010)

Thrombin is a potent modulator of endothelial function and, through stimulation of NF-κB, induces endothelial expression of intracellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1). These cell surface adhesion molecules recrui...

Platelets made HLA deficient by acid treatment aggregate normally and escape destruction by complement and phagocytes in the presence of HLA antibodies.

Transfusion 56 , 370-82; quiz 369, (2016)

The presence of antibodies against HLA Class I can lead to platelet (PLT) transfusion refractoriness, that is, the repeated failure to achieve adequate posttransfusion PLT count increments. PLT refractoriness can be overcome by transfusion of HLA-matched dono...

Additive solutions differentially affect metabolic and functional parameters of platelet concentrates.

Vox Sang. 110 , 20-Jun, (2016)

Pathogen inactivation (PI) of platelet concentrates with extension of shelf life to 7 days requires the use of platelet additive solutions (PAS). We examined the quality of platelets resuspended in three different PAS stored for up to 7 days.Twelve triple adu...