NS-1619
NS-1619 structure
|
Common Name | NS-1619 | ||
|---|---|---|---|---|
| CAS Number | 153587-01-0 | Molecular Weight | 362.22700 | |
| Density | 1.563g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C15H8F6N2O2 | Melting Point | 234 °C(dec.) | |
| MSDS | Chinese USA | Flash Point | N/A | |
|
Potassium channel openers prevent palmitate-induced insulin resistance in C2C12 myotubes.
Arch. Biochem. Biophys. 541 , 47-52, (2014) Insulin resistance (IR) of muscle cells is an early symptom of type 2 diabetes. It often results from excessive lipid accumulation in muscle fibers which under in vitro experimental conditions may be induced by incubation of muscle cells with palmitate. IR is... |
|
|
Potassium ion channels and allergic asthma.
Adv. Exp. Med. Biol. 838 , 35-45, (2015) High-conductive calcium-sensitive potassium channels (BK+Ca) and ATP-sensitive potassium (K+ATP) channels play a significant role in the airway smooth muscle cell and goblet cell function, and cytokine production. The present study evaluated the therapeutic p... |
|
|
High glucose alters apoptosis and proliferation in HEK293 cells by inhibition of cloned BK Ca channel.
J. Cell Physiol. 226(6) , 1660-75, (2011) It has been reported that diabetic vascular dysfunction is associated with impaired function of large conductance Ca(2+) -activated K(+) (BK(Ca) ) channels. However, it is unclear whether impaired BK(Ca) channel directly participates in regulating diabetic va... |
|
|
Impairment of neurovascular coupling in type 1 diabetes mellitus in rats is linked to PKC modulation of BK(Ca) and Kir channels.
Am. J. Physiol. Heart Circ. Physiol. 302(6) , H1274-84, (2012) We hypothesized that chronic hyperglycemia has a detrimental effect on neurovascular coupling in the brain and that this may be linked to protein kinase C (PKC)-mediated phosphorylation. Therefore, in a rat model of streptozotocin-induced chronic type 1 diabe... |
|
|
Functional and molecular characterization of maxi K+ -channels (BK(Ca)) in buffalo myometrium.
Anim. Reprod. Sci. 126(3-4) , 173-8, (2011) Large conductance potassium channels (BK(Ca) channels) play a central role in maintaining myometrial tone, thus activation of these channels proved to have therapeutic potential in preterm labor. Present study aims to unravel the presence of BK(Ca) (maxi-K) c... |
|
|
Mitochondrial K+ channels are involved in ischemic postconditioning in rat hearts.
J. Physiol. Sci. 62(4) , 325-32, (2012) The mitochondrial calcium-activated potassium channel (mitoK(Ca)) and the mitochondrial ATP-sensitive potassium channel (mitoK(ATP)) are both involved in cardiac preconditioning. Here, we examined whether these two channels are also involved in ischemic or ph... |
|
|
Splicing of the rSlo gene affects the molecular composition and drug response of Ca2+-activated K+ channels in skeletal muscle.
PLoS ONE 7(7) , e40235, (2012) The molecular composition and drug responses of calcium-activated K(+) (BK) channels of skeletal muscle are unknown. Patch-clamp experiments combined with transcript scanning of the Kcnma1 gene encoding the alpha subunit of the BK channel were performed in ra... |
|
|
Methamphetamine inhibits voltage-gated potassium currents in NG108-15 cells: possible contribution of large-conductance calcium-activated potassium channels.
Toxicol. Lett. 223(2) , 139-45, (2013) Methamphetamine (MA), a highly abused amphetamine-like psychostimulant, has surged in popularity worldwide in the last decade. Repeated MA exposure has been shown to affect the alternative splice variant expression of large conductance Ca(2+)-activated K(+) (... |
|
|
Role of ROS/RhoA/PI3K/PKB signaling in NS1619-mediated blood-tumor barrier permeability increase.
J. Mol. Neurosci. 48(1) , 302-12, (2012) The calcium-activated potassium channel (K (Ca) channel) activator, NS1619, has been shown to selectively and time-dependently increase the permeability of the blood-tumor barrier (BTB) by downregulating the expression of tight junction (TJ) protein. However,... |
|
|
Cytoprotective action of the potassium channel opener NS1619 under conditions of disrupted calcium homeostasis.
Pharmacol. Rep. 63(1) , 176-83, (2011) Cytoprotective properties of potassium channel openers (KCOs) have been demonstrated in several models of cell injury, mainly in ischemia-reperfusion-induced damage of cardiac muscle. The mechanism responsible for the observed cytoprotection and the relative ... |