SR-12813
SR-12813 structure
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Common Name | SR-12813 | ||
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| CAS Number | 126411-39-0 | Molecular Weight | 504.53400 | |
| Density | 1.117g/cm3 | Boiling Point | 552.6ºC at 760mmHg | |
| Molecular Formula | C24H42O7P2 | Melting Point | N/A | |
| MSDS | USA | Flash Point | 288ºC | |
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Dehydroepiandrosterone induces human CYP2B6 through the constitutive androstane receptor.
Drug Metab. Dispos. 35 , 1495-501, (2007) Dehydroepiandrosterone (DHEA), the major precursor of androgens and estrogens, has several beneficial effects on the immune system, on memory function, and in modulating the effects of diabetes, obesity, and chemical carcinogenesis. Treatment of rats with DHE... |
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Cyclin-dependent kinase 2 negatively regulates human pregnane X receptor-mediated CYP3A4 gene expression in HepG2 liver carcinoma cells.
J. Biol. Chem. 283 , 30650-7, (2008) The human pregnane X receptor (hPXR) regulates the expression of critical drug metabolism enzymes. One of such enzymes, cytochrome P450 3A4 (CYP3A4), plays critical roles in drug metabolism in hepatocytes that are either quiescent or passing through the cell ... |
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Isolation of mutant cells lacking Insig-1 through selection with SR-12813, an agent that stimulates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
J. Biol. Chem. 279 , 43136-47, (2004) Insig-1 and Insig-2 are membrane proteins of the endoplasmic reticulum that regulate lipid metabolism by the following two actions: 1) sterol-induced binding to 3-hydroxy-3-methylglutaryl-coenzyme A reductase, an action that leads to ubiquitination and degrad... |
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The novel cholesterol-lowering drug SR-12813 inhibits cholesterol synthesis via an increased degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
J. Biol. Chem. 271 , 14376-14382, (1996) SR-12813 (tetra-ethyl 2-(3,5-di-tert-butyl-4-hydroxyphenyl)ethenyl-1, 1-bisphosphonate) lowers plasma cholesterol in five species. In this paper we investigate the underlying mechanism using Hep G2 cells. SR-12813 inhibited incorporation of tritiated water in... |