GSK0660
GSK0660 structure
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Common Name | GSK0660 | ||
|---|---|---|---|---|
| CAS Number | 1014691-61-2 | Molecular Weight | 418.487 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 608.1±65.0 °C at 760 mmHg | |
| Molecular Formula | C19H18N2O5S2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 321.5±34.3 °C | |
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Foam cell-derived 4-hydroxynonenal induces endothelial cell senescence in a TXNIP-dependent manner.
J. Cell. Mol. Med. 19 , 1887-99, (2015) Vascular endothelial cell (VEC) senescence is considered an early event in the development of atherosclerotic lesions. Stressful stimuli, in particular oxidative stress, have been linked to premature senescence in the vasculature. Foam cells are a major sourc... |
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Activation of PPAR-δ induces microRNA-100 and decreases the uptake of very low-density lipoprotein in endothelial cells.
Br. J. Pharmacol. 172(15) , 3728-36, (2015) Increased level of very low-density lipoprotein (VLDL) is a key feature of the metabolic syndrome and is associated with cardiovascular diseases. PPAR-δ agonists play a protective role in lipid metabolism and vascular function. In this study, we aimed to inve... |
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The triggering receptor expressed on myeloid cells 2 inhibits complement component 1q effector mechanisms and exerts detrimental effects during pneumococcal pneumonia.
PLoS Pathog. 10(6) , e1004167, (2014) Phagocytosis and inflammation within the lungs is crucial for host defense during bacterial pneumonia. Triggering receptor expressed on myeloid cells (TREM)-2 was proposed to negatively regulate TLR-mediated responses and enhance phagocytosis by macrophages, ... |
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Mechanisms of Nifedipine-Downregulated CD40L/sCD40L Signaling in Collagen Stimulated Human Platelets.
PLoS ONE 10 , e0127054, (2015) The platelet-derived soluble CD40L (sCD40L) release plays a critical role in the development of atherosclerosis. Nifedipine, a dihydropyridine-based L-type calcium channel blocker (CCB), has been reported to have an anti-atherosclerotic effect beyond its bloo... |
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Peroxisome proliferator-activated receptor δ modulates MMP-2 secretion and elastin expression in human dermal fibroblasts exposed to ultraviolet B radiation.
J. Dermatol. Sci. 76(1) , 44-50, (2014) Changes in skin connective tissues mediated by ultraviolet (UV) radiation have been suggested to cause the skin wrinkling normally associated with premature aging of the skin. Recent investigations have shown that peroxisome proliferator-activated receptor (P... |
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Development of telmisartan in the therapy of spinal cord injury: pre-clinical study in rats.
Drug Des. Devel. Ther. 9 , 4709-17, (2015) Decrease of peroxisome proliferator-activated receptors-δ (PPARδ) expression has been observed after spinal cord injury (SCI). Increase of PPARδ may improve the damage in SCI. Telmisartan, the antihypertensive agent, has been mentioned to increase the express... |
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Retinoid resistance and multifaceted impairment of retinoic acid synthesis in glioblastoma.
Glia 63 , 1850-9, (2015) Measuring concentrations of the differentiation-promoting hormone retinoic acid (RA) in glioblastoma tissues would help to understand the reason why RA treatment has been inefficient in clinical trials involving brain tumor patients. Here, we apply a recently... |
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Inhibition of soluble epoxide hydrolase prevents renal interstitial fibrosis and inflammation.
Am. J. Physiol. Renal Physiol. 307(8) , F971-80, (2014) The pathophysiological events that lead to renal interstitial fibrogenesis are incompletely understood. Epoxyeicosatrienoic acid (EET), an arachidonic acid metabolite, has anti-inflammatory and profibrinolytic functions. Soluble epoxide hydrolase (sEH) conver... |