SQ22536
SQ22536 structure
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Common Name | SQ22536 | ||
|---|---|---|---|---|
| CAS Number | 17318-31-9 | Molecular Weight | 205.217 | |
| Density | 1.7±0.1 g/cm3 | Boiling Point | 474.8±55.0 °C at 760 mmHg | |
| Molecular Formula | C9H11N5O | Melting Point | 160-161ºC | |
| MSDS | USA | Flash Point | 241.0±31.5 °C | |
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Compartmentalization of distinct cAMP signaling pathways in mammalian sperm.
J. Biol. Chem. 288(49) , 35307-20, (2013) Fertilization competence is acquired in the female tract in a process known as capacitation. Capacitation is needed for the activation of motility (e.g. hyperactivation) and to prepare the sperm for an exocytotic process known as acrosome reaction. Although t... |
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Ibudilast, a mixed PDE3/4 inhibitor, causes a selective and nitric oxide/cGMP-independent relaxation of the intracranial vertebrobasilar artery.
Eur. J. Pharmacol. 650(2-3) , 605-11, (2011) Ibudilast, a mixed phosphodiesterase (PDE) 3/4 inhibitor, is a cerebral vasodilator widely used in Japan for treating post-stroke dizziness. However, little studies have been conducted on the vasorelaxant effects of PDE inhibitors in the vertebrobasilar arter... |
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IL-6, A1 and A2aR: a crosstalk that modulates BDNF and induces neuroprotection.
Biochem. Biophys. Res. Commun. 449(4) , 477-82, (2014) Several diseases are related to retinal ganglion cell death, such as glaucoma, diabetes and other retinopathies. Many studies have attempted to identify factors that could increase neuroprotection after axotomy of these cells. Interleukin-6 has been shown to ... |
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Systems pharmacology identifies drug targets for Stargardt disease-associated retinal degeneration.
J. Clin. Invest. 123(12) , 5119-34, (2013) A systems pharmacological approach that capitalizes on the characterization of intracellular signaling networks can transform our understanding of human diseases and lead to therapy development. Here, we applied this strategy to identify pharmacological targe... |
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Intermedin enhances sympathetic outflow via receptor-mediated cAMP/PKA signaling pathway in nucleus tractus solitarii of rats.
Peptides 47 , 1-6, (2013) Direct administration of intermedin (IMD) into the brain elicits cardiovascular effects different from the systemic administration. Nucleus tractus solitarii (NTS) is an important region for the cardiovascular regulation. The present study was designed to det... |
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Mechanism of PKA-dependent and lipid-raft independent stimulation of Connexin43 expression by oxytoxin in mouse embryonic stem cells.
Mol. Endocrinol. 26(7) , 1144-57, (2012) Previous studies shows that connexins appear very early during murine embryo development, the gap junctional intercellular communication found in the inner cell mass of early embryo is also maintained in embryonic stem cells (ESC), and expression of oxytocin ... |
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Involvement of cAMP in nerve growth factor-triggered p35/Cdk5 activation and differentiation in PC12 cells.
Am. J. Physiol. Cell Physiol. 299 , C516-27, (2010) The signaling mechanisms underlying cell differentiation have been extensively studied with the use of rat PC12 cells as a model system. Nerve growth factor (NGF) is a trophic factor inducing PC12 cell differentiation through the activation of the p35/cyclin-... |
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Functional and molecular characterization of prostaglandin E2 dilatory receptors in the rat craniovascular system in relevance to migraine.
Cephalalgia 30(9) , 1110-22, (2010) Migraine pain is thought to involve an increase in trigeminal nerve terminal activity around large cerebral and meningeal arteries, leading to vasodilatation. Because prostaglandin E(2) (PGE(2)) is elevated in cephalic venous blood during migraine attacks, an... |
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Facilitation of corticostriatal transmission following pharmacological inhibition of striatal phosphodiesterase 10A: role of nitric oxide-soluble guanylyl cyclase-cGMP signaling pathways.
J. Neurosci. 35(14) , 5781-91, (2015) The striatum contains a rich variety of cyclic nucleotide phosphodiesterases (PDEs), which play a critical role in the regulation of cAMP and cGMP signaling. The dual-substrate enzyme PDE10A is the most highly expressed PDE in striatal medium-sized spiny neur... |
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Prostaglandin E2 promotes liver cancer cell growth by the upregulation of FUSE-binding protein 1 expression.
Int. J. Oncol. 42(3) , 1093-104, (2013) Liver cancer is a common human cancer with a high mortality rate and currently there is no effective chemoprevention or systematic treatment. Recent evidence suggests that prostaglandin E(2) (PGE(2)) plays an important role in the occurrence and development o... |