Deguelin
Deguelin structure
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Common Name | Deguelin | ||
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| CAS Number | 522-17-8 | Molecular Weight | 394.417 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 560.1±50.0 °C at 760 mmHg | |
| Molecular Formula | C23H22O6 | Melting Point | 85-87ºC(lit.) | |
| MSDS | USA | Flash Point | 244.7±30.2 °C | |
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Concise modular asymmetric synthesis of deguelin, tephrosin and investigation into their mode of action.
Chemistry 16(32) , 9767-71, (2010)
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In vitro approach to predict post-translational phosphorylation response to mixtures.
Toxicology 313(2-3) , 113-21, (2013) While exposure to chemical mixtures is an everyday reality, an understanding of their combined effects, and any potential prediction thereof, is extremely limited. Realistic exposures potentially consist of hundreds to thousands of chemicals per day, but even... |
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Exploring the boundaries of additivity: mixtures of NADH: quinone oxidoreductase inhibitors.
Chem. Res. Toxicol. 24(8) , 1242-50, (2011) The activity of mitochondrial complex I of the electron transport chain (ETC) is known to be affected by an extraordinarily large number of diverse xenobiotics, and dysfunction at complex I has been associated with a variety of disparate human diseases, inclu... |
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Efficacy and mechanism of action of Deguelin in suppressing metastasis of 4T1 cells.
Clin. Exp. Metastasis 30(7) , 855-66, (2013) Cancer related deaths in breast cancer patients are due to metastasis of the disease. Murine 4T1 cells (Murine mammary cancer cell line developed from 6-thioguanine resistant tumor) provide an excellent research tool for metastasis related studies because the... |
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A novel antitumor activity of deguelin targeting the insulin-like growth factor (IGF) receptor pathway via up-regulation of IGF-binding protein-3 expression in breast cancer.
Cancer Lett. 332(1) , 102-9, (2013) In this study, we investigated the antitumor effects of deguelin in several human breast cancer cells in vitro and in vivo. Deguelin inhibited cell viability and the anchorage-dependent and anchorage-independent colony formation of triple-negative (MDA-MB-231... |
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Deguelin induces both apoptosis and autophagy in cultured head and neck squamous cell carcinoma cells.
PLoS ONE 8(1) , e54736, (2013) Head and neck squamous cell carcinoma (HNSCC) represents more than 5% of all cancers diagnosed annually in United States and around the world. Despite advances in the management of patients with this disease, the survival has not been significantly improved, ... |
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Role for pAKT in rat urinary bladder with cyclophosphamide (CYP)-induced cystitis.
Am. J. Physiol. Renal Physiol. 301(2) , F252-62, (2011) AKT phosphorylation following peripheral nerve injury or inflammation may play a role in somatic pain processes and visceral inflammation. To examine such a role in micturition reflexes with bladder inflammation, we induced bladder inflammation in adult femal... |
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Liposomal encapsulation of deguelin: evidence for enhanced antitumor activity in tobacco carcinogen-induced and oncogenic K-ras-induced lung tumorigenesis.
Cancer Prev. Res. (Phila.) 2(4) , 361-9, (2009) Deguelin has shown promising chemopreventive and therapeutic activities in diverse types of cancers. However, the potential side effect of deguelin over a certain dose could be the substantial hurdle in the practical application of the drug. One of the succes... |
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Chronic Akt blockade aggravates pathological hypertrophy and inhibits physiological hypertrophy.
Am. J. Physiol. Heart Circ. Physiol. 302(2) , H420-30, (2012) The attenuation of adverse myocardial remodeling and pathological left ventricular (LV) hypertrophy is one of the hallmarks for improving the prognosis after myocardial infarction (MI). The protein kinase Akt plays a central role in regulating cardiac hypertr... |
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Deguelin--an inhibitor to tumor lymphangiogenesis and lymphatic metastasis by downregulation of vascular endothelial cell growth factor-D in lung tumor model.
Int. J. Cancer 127(10) , 2455-66, (2010) Deguelin, a rotenoid of the flavonoid family, has been reported to possess antiproliferative and anticarcinogenic activities in several cell lines and tumor models. However, it is still unclear whether deguelin effectively inhibits tumor-associated lymphangio... |