NS-102
NS-102 structure
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Common Name | NS-102 | ||
|---|---|---|---|---|
| CAS Number | 136623-01-3 | Molecular Weight | 261.23300 | |
| Density | 1.74g/cm3 | Boiling Point | 405.8ºC at 760mmHg | |
| Molecular Formula | C12H11N3O4 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 199.2ºC | |
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Selective block of recombinant glur6 receptors by NS-102, a novel non-NMDA receptor antagonist.
Eur. J. Pharmacol. 269 , 43, (1994) The diversity of neuronal glutamate receptors continues to increase with the discovery of multiple subunits and subunit families. The significance of this potential receptor heterogeneity is unknown because pharmacological tools that could clearly distinguish... |
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A novel non-NMDA receptor antagonist shows selective displacement of low-affinity [3H]kainate binding.
Eur. J. Pharmacol. 246 , 195, (1993) 5-Nitro-6,7,8,9-tetrahydrobenzo[G]indole-2,3-dione-3-oxime (NS-102), a new competitive glutamate receptor antagonist displaced binding to non-N-methyl-D-aspartate (non-NMDA) binding sites with no activity at the NMDA and strychnine-insensitive glycine binding... |
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Kainate receptor-mediated inhibition of presynaptic Ca2+ influx and EPSP in area CA1 of the rat hippocampus.
J. Physiol. 509 ( Pt 3) , 833-45, (1998) 1. The effect of a low concentration (1 microM) of kainate (kainic acid; KA) on presynaptic calcium (Ca2+) influx at the Schaffer collateral-commissural (SCC) synapse was examined in rat hippocampal slices. 2. Following selective loading of the presynaptic te... |
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Acute and late effects on induction of allodynia by acromelic acid, a mushroom poison related structurally to kainic acid.
Br. J. Pharmacol. 142(4) , 679-88, (2004) 1. Ingestion of a poisonous mushroom Clitocybe acromelalga is known to cause severe tactile pain (allodynia) in the extremities for a month and acromelic acid (ACRO), a kainate analogue isolated from the mushroom, produces selective damage of interneurons of ... |
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Selective reduction in domoic acid toxicity in vivo by a novel non-N-methyl-D-aspartate receptor antagonist.
Can. J. Physiol. Pharmacol. 74(9) , 1047-54, (1996) Our objective was to characterize the neurotoxic actions of systemically administered domoic acid on different excitatory amino acid receptors, and to compare the receptor selectivity of domoate with the related compound kainic acid. Groups of mice were injec... |
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Glutamate receptor agonist kainate enhances primary dendrite number and length from immature mouse cortical neurons in vitro.
J. Neurosci. Res. 83(6) , 944-56, (2006) Glutamate is an important regulator of dendrite development that may inhibit, (during ischemic injury), or facilitate (during early development) dendrite growth. Previous studies have reported mainly on the N-methyl-D-aspartate (NMDA) receptor-mediated dendri... |
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Low-affinity kainate receptors and long-lasting depression of NMDA-receptor-mediated currents in rat superficial dorsal horn.
J. Neurophysiol. 80(2) , 895-902, (1998) In an in vitro spinal cord slice preparation whole cell electrophysiological recordings of rat superficial dorsal horn neurons responding differentially to glutamate (Glu) and N-methyl-D-aspartate (NMDA) were investigated systematically for the role of kainat... |