1-o-hexadecyl-2-acetyl-sn-glycero-3
1-o-hexadecyl-2-acetyl-sn-glycero-3 structure
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Common Name | 1-o-hexadecyl-2-acetyl-sn-glycero-3 | ||
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| CAS Number | 99103-16-9 | Molecular Weight | 580.79700 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C30H63NO7P+ | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
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[Interactions of PAF and its antagonists in the guinea pig atrial myocardium].
Biull. Eksp. Biol. Med. 108(8) , 137-9, (1989) The effects of platelet activating factor (PAF) and three its antagonists on the transmembrane intracellular potentials and stimulated (0.5 Hz) contraction amplitude (CA) of the left auricle has been studied. PAF (1-5 X 10(-7) M) was added to the standard Tyr... |
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[The blocking action of platelet-activating factor (PAF) on the calcium currents of the atrial fibers in the frog and guinea pig].
Biull. Eksp. Biol. Med. 108(12) , 643-6, (1989) The effects of platelet-activating factor (PAF) on the myocardial cell membrane Ca-current (ICa) and Ca-action potential (Ca-AP) were investigated. In double sucrose-gap voltage-clamped frog atrial trabeculae PAF (2 X 10(-7) M) reduced ICa-amplitude to 40-50%... |
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On the mechanisms of action of PAF on the myocardium.
Bratisl. Lek. Listy 92(3-4) , 159-64, (1991) The effects of PAF (1-2 X 10(-7) M) on intracellular slow Ca-mediated action potentials (Ca-AP) and isometric contractions of guinea-pig auricle muscles and ionic currents of frog atrial trabeculae were investigated. PAF decreased the amplitude, duration and ... |
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Structural analogs of alkylacetylglycerophosphocholine inhibitory behavior on platelet activation.
J. Biol. Chem. 260(23) , 12710-4, (1985) Several analogs of alkylacetylglycerophosphocholine (AGEPC; platelet-activating factor) were investigated as potential selective inhibitors of AGEPC-induced activation of washed rabbit platelets. Two particular compounds, CV-3988 (rac-3-(N-n-octadecylcarbamoy... |
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Binding and internalization of platelet-activating factor 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine in washed rabbit platelets.
J. Biol. Chem. 262(22) , 10582-7, (1987) The binding profile of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (AGEPC, platelet-activating factor) to washed rabbit platelets was investigated through the use of structural analogs of AGEPC, e.g. U66985, which specifically suppressed AGEPC biological a... |
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Specific antagonists of platelet activating factor-mediated vasoconstriction and glycogenolysis in the perfused rat liver.
Biochem. Pharmacol. 35(6) , 893-7, (1986) Stimulation of hepatic glycogenolysis and vasoconstriction of the hepatic vasculature in response to acetyl glyceryl ether phosphocholine (AGEPC; platelet activating factor) was inhibited by two structural analogues of AGEPC, U66985 (1-O-octadecyl-2-O-acetyl-... |
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Two distinct pathways of platelet-activating factor-induced hydrolysis of phosphoinositides in primary cultures of rat Kupffer cells.
J. Biol. Chem. 265(30) , 18234-41, (1990) Stimulation of rat Kupffer cells in primary culture with platelet-activating factor (PAF) caused a rapid hydrolysis of phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 4-phosphate with a concomitant increase in the levels of myo-inositol 1,4,5-t... |
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Electrophysiological mechanisms responsible for the action of PAF in guinea-pig myocardium. Relation to the putative membrane signalling processes of PAF.
J. Lipid Mediat. 3(2) , 139-59, (1991) The effects of platelet-activating factor (PAF) on intracellular action potentials and isometric contractions of guinea-pig auricle muscle and ionic currents of frog atrial trabeculae were investigated. Experiments to study the effects of PAF on ionic current... |
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Attenuation of platelet activating factor (PAF)-induced stimulation of rabbit platelet GTPase by phorbol ester, dibutyryl cAMP, and desensitization: concomitant effects on PAF receptor binding characteristics.
Arch. Biochem. Biophys. 262(1) , 32-9, (1988) The GTPase activities of rabbit platelet membrane were stimulated by platelet activating factor (PAF) in a receptor-mediated manner. The activities of the GTPase were investigated in the platelets which had been pretreated with tetradecanoyl phorbol acetate (... |
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Characterization of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (AGEPC)-induced protein phosphorylation in rabbit platelets: inhibitory effects of AGEPC analogs.
Arch. Biochem. Biophys. 246(2) , 855-64, (1986) 1-O-Alkyl-2-acetyl-sn-glycero-3-phosphocholine (AGEPC) induced phosphorylation of two proteins having molecular masses of approximately 20- and 40-kDa in washed rabbit platelets in a concentration- and time-dependent manner. Sequential stimulation with AGEPC ... |