VIP (human, mouse, rat) acetate salt

VIP (human, mouse, rat) acetate salt Structure
VIP (human, mouse, rat) acetate salt structure
Common Name VIP (human, mouse, rat) acetate salt
CAS Number 40077-57-4 Molecular Weight 3325.797
Density 1.5±0.1 g/cm3 Boiling Point N/A
Molecular Formula C147H238N44O42S Melting Point N/A
MSDS USA Flash Point N/A

Amyloid precursor protein mediated changes in intestinal epithelial phenotype in vitro.

PLoS ONE 10(3) , e0119534, (2015)

Although APP and its proteolytic metabolites have been well examined in the central nervous system, there remains limited information of their functions outside of the brain. For example, amyloid precursor protein (APP) and amyloid beta (Aβ) immunoreactivity ...

Distinct roles for GABA across multiple timescales in mammalian circadian timekeeping.

Proc. Natl. Acad. Sci. U. S. A. 112 , E3911-9, (2015)

The suprachiasmatic nuclei (SCN), the central circadian pacemakers in mammals, comprise a multiscale neuronal system that times daily events. We use recent advances in graphics processing unit computing to generate a multiscale model for the SCN that resolves...

High-mobility group box 1: a novel target for treatment of Pseudomonas aeruginosa keratitis.

J. Immunol. 194(4) , 1776-87, (2015)

High-mobility group box 1 (HMGB1), a prototypic alarmin, mediates the systemic inflammatory response syndrome. Treatment with vasoactive intestinal peptide, an anti-inflammatory neuropeptide, downregulates proinflammatory cytokines and promotes healing in a s...

Phenotypic malignant changes and untargeted lipidomic analysis of long-term exposed prostate cancer cells to endocrine disruptors.

Environ. Res. 140 , 18-31, (2015)

Endocrine disruptors (EDs) are a class of environmental toxic molecules able to interfere with the normal hormone metabolism. Numerous studies involve EDs exposure to initiation and development of cancers, including prostate cancer. In this work, three differ...

Circadian rhythm disruption in a mouse model of Rett syndrome circadian disruption in RTT.

Neurobiol. Dis. 77 , 155-64, (2015)

Disturbances in the sleep/wake cycle are prevalent in patients with Rett syndrome (RTT). We sought to determine whether the circadian system is disrupted in a RTT model, Mecp2(-/y) mice. We found that MeCP2 mutants showed decreased strength and precision of d...

Synoviocyte Derived-Extracellular Matrix Enhances Human Articular Chondrocyte Proliferation and Maintains Re-Differentiation Capacity at Both Low and Atmospheric Oxygen Tensions.

PLoS ONE 10(6) , e0129961, (2015)

Current tissue engineering methods are insufficient for total joint resurfacing, and chondrocytes undergo de-differentiation when expanded on tissue culture plastic. De-differentiated chondrocytes show poor re-differentiation in culture, giving reduced glycos...

Uncovering caffeine's adenosine A2A receptor inverse agonism in experimental parkinsonism.

ACS Chem. Biol. 9(11) , 2496-501, (2014)

Caffeine, the most consumed psychoactive substance worldwide, may have beneficial effects on Parkinson's disease (PD) therapy. The mechanism by which caffeine contributes to its antiparkinsonian effects by acting as either an adenosine A2A receptor (A2AR) neu...

Darkness during early postnatal development is required for normal circadian patterns in the adult rat.

Chronobiol. Int. 32(2) , 178-86, (2015)

Early light experience influences the brain during development. Perinatal light exposure has an important effect on the development of the circadian system, although the role of quantity versus quality of light in this process is still unclear. We tested the ...

S-SCAM, a rare copy number variation gene, induces schizophrenia-related endophenotypes in transgenic mouse model.

J. Neurosci. 35(5) , 1892-904, (2015)

Accumulating genetic evidence suggests that schizophrenia (SZ) is associated with individually rare copy number variations (CNVs) of diverse genes, often specific to single cases. However, the causality of these rare mutations remains unknown. One of the rare...

Partial depletion of the proinflammatory monocyte population is neuroprotective in the myenteric plexus but not in the basal ganglia in a MPTP mouse model of Parkinson's disease.

Brain. Behav. Immun. 46 , 154-67, (2015)

Parkinson's disease (PD) patients often suffer from gastrointestinal (GI) impairments that are associated with the alteration of dopaminergic (DAergic) neurons in the myenteric nervous system. Growing evidence suggests that inflammation originating from the g...